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FLASH GENE
Symbol RFC4 contributors: mlc/npt - updated : 12-01-2008
HGNC name replication factor C (activator 1) 4, 37kDa
HGNC id 9972
Location 3q27      Physical location : 186.507.683 - 186.524.484
Synonym name
  • RFC 37 kDa subunit
  • activator 1 37 kDa subunit
  • Synonym symbol(s) A1, MGC27291, RFC37
    DNA
    TYPE functioning gene
    STRUCTURE 16.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ETV5 3q28 ets variant gene 5 (ets-related molecule) DGKG 3q27-q28 diacylglycerol kinase, gamma 90kDa CRYGS 3q25-q28 crystallin, gamma S FLJ10560 3q28 hypothetical protein FLJ10560 DNAJB11 3q28 DnaJ (Hsp40) homolog, subfamily B, member 11 AHSG 3q27 alpha-2-HS-glycoprotein FETUB 3q27 fetuin B HRG 3q27 histidine-rich glycoprotein LOC391602 3 similar to Histidine-rich glycoprotein precursor (Histidine-proline rich glycoprotein) (HPRG) KNG 3q27 kininogen LOC280644 3q28 proteasome 26S non-ATPase subunit 10 pseudogene EIF4A2 3q28 eukaryotic translation initiation factor 4A, isoform 2 RFC4 3q27 replication factor C (activator 1) 4, 37kDa LOC389183 3 hypothetical gene supported by BC028116 LOC389184 3 LOC389184 APM1 3q27 LOC389184 LOC285384 3q28 similar to 40S ribosomal protein S20 LOC339928 3q28 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) SIAT1 3q27-q28 sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase) RPL39L 3q27 ribosomal protein L39-like MGC35450 3q28 hypothetical protein MGC35450 MASP1 3q27-q28 mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor) IFRG28 3q28 28kD interferon responsive protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1427 39.7 363 - Gupte (2005)
    12 - 1395 39.7 363 - Gupte (2005)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
    Endocrineneuroendocrinepituitary  highly
    Reproductivemale systemprostate   
    Respiratoryrespiratory tractlarynx  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PCNA binding region
  • an ATP binding domain
  • a DEAD/H box (Asp-Glu-Ala-Asp/His)
  • mono polymer heteromer , pentamer
    HOMOLOGY
    interspecies homolog to Drosophila CG8142
    homolog to C.elegans rfc-4
    Homologene
    FAMILY
  • activator 1,36 to 40 kDa subunits family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • activator of DNA polymerases
  • maybe involved in the elongation of multiprimed DNA template
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of complex A-1, DNA polymerase accessory protein "clamp loader", ATP dependent, required to assemble PCNA and polymerase delta on the DNA template
  • heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to PCNA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS