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FLASH GENE
Symbol REXO1 contributors: mct - updated : 12-04-2016
HGNC name REX1, RNA exonuclease 1 homolog (S. cerevisiae)
HGNC id 24616
Location 19p13.3      Physical location : 1.815.245 - 1.848.452
Synonym name
  • elongin A binding protein 1
  • RNA exonuclease 1 homolog
  • transcription elongation factor B polypeptide 3 binding protein 1
  • Synonym symbol(s) ELOABP1, KIAA1138, TCEB3BP1, REX1
    EC.number 3.1.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 33.24 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 4581 - 1221 - 2003 12943681
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Endocrineplacenta    
    Lymphoid/Immunelymph node    
    Reproductivefemale systemovary   
     male systemtestis   
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an exonuclease domain
  • HOMOLOGY
    interspecies homolog to murine Rexo1 (79 pc)
    Homologene
    FAMILY REXO1/REXO3 family
    CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as an exonuclease
  • may play some role in the regulation of elongation
  • critically important for efficient transcription elongation of TSIX
  • CELLULAR PROCESS nucleotide, transcription, elongation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RLIM targets REXO1, an inhibitor of X chromosome inactivation (XCI), for proteasomal degradation, regulating initiation of XCI
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS