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FLASH GENE
Symbol REV3L contributors: mct - updated : 31-05-2015
HGNC name REV3-like, catalytic subunit of DNA polymerase zeta (yeast)
HGNC id 9968
Location 6q21      Physical location : 111.620.234 - 111.804.414
Synonym symbol(s) POLZ, REV3
EC.number 2.7.7.7
DNA
TYPE functioning gene
STRUCTURE 184.68 kb     34 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
34 - 10850 - 3130 - 1998 9635887
34 - 10982 - 3052 - 1998 9635887
35 - 11089 - 3052 - 1998 9635887
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast S.cerevisiae REV3
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
text
  • REV3L and MAD2L2 show an unexpected increase in expression during G(2)/M phase, but they localize independently in mitotic cells
    • basic FUNCTION
  • DNA polymerase, zeta, catalytic subunit, involved in reduction of DNA damage, (tissue-specific) used in translesion replication
  • low fidelity and error prone,acting sequentially after POLI as a mispair extender
  • is believed to play a role in double-strand break (DSB)-induced DNA repair by homologous recombination
  • REV1, REV3L and MAD2L2 play important roles in translesion DNA synthesis (TLS) in which DNA replication bypasses blocking lesions
  • is unique amongst translesion synthesis (TLS) polymerases for its essential role in cell proliferation
  • REV1, REV3L, and MAD2L2 are pivotal proteins in translesion DNA synthesis, which allows DNA synthesis even in the presence of DNA damage
  • biological role for REV3L in tolerating DNA damage and enabling proliferative responses
  • required for the efficient replication of CFSs during G(2)/M phase
  • involved in translesion DNA synthesis (TLS), is capable of synthesizing directly across template DNA lesions
    • CELLULAR PROCESS nucleotide, repair
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • REV1/REV3L complex maintains genomic stability by directly participating in DSB repair in addition to the canonical TLS pathway
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    might have occurred early during tumorigenesis
    constitutional germinal mutation      
    in PLXND1 and REV3L that are responsible for a proportion of Möbius syndrome (MBS) patients suggesting that de novo mutations in other genes might account for other MBS patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS