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FLASH GENE
Symbol REV1 contributors: mct - updated : 31-05-2014
HGNC name REV1 homolog (S. cerevisiae)
HGNC id 14060
Location 2q11.2      Physical location : 100.016.938 - 100.106.480
Synonym name
  • deoxycytidyl (dCMP)-transferase
  • REV1-like (yeast)
  • Rev1-like terminal deoxycytidyl transferase
  • alpha integrin-binding protein 80
  • DNA repair protein REV1
  • Synonym symbol(s) DCMPT, REV1L, AIBP80, FLJ21523, MGC163283, MGC26225
    EC.number 2.7.7.-
    DNA
    TYPE functioning gene
    STRUCTURE 89.56 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 4751 138.2 1251 - 2006 16803901
    23 - 4748 - 1250 - 2006 16803901
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  predominantly
     mouthtongue  highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systembreastmammary gland highly
     female systemuterus  highly
    Respiratorylung   moderately
    Urinarybladder   highly
     kidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N terminal BRCT found in BRCA1 and proteins, involved in cell-cycle checkpoints and important in protein-protein interactions
  • five conserved motifs closely ressembling E coli UmuC related proteins
  • ubiquitin-binding motifs (UBMs) located at the C terminus, required for its role in the tolerance of DNA damage
  • a BRCT domain
  • C-terminal domain adopts a four-helix bundle that interacts with MAD2L2
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae REV1
    ortholog to murine Rev1l
    homolog to drosophila Rev1
    intraspecies homolog to mutagenic protein
    Homologene
    FAMILY
  • DNA polymerase type-Y family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • deoxycytidyl (dCMP)-transferase, template DNA dependent, specifically inserting a dCMP residue
  • required for mutagenesis induced by UV light
  • opposite a DNA template G and opposite an apurinic site
  • involved in the tolerance of DNA damage by translesion DNA synthesis
  • playing an important role for maintaining genetic integrity through translesion DNA synthesis
  • involved in the tolerance of DNA damage by replicative bypass
  • REV1, REV3L and MAD2L2 play important roles in translesion DNA synthesis (TLS) in which DNA replication bypasses blocking lesions (pMID: 21926160)
  • translesion synthesis (TLS) DNA polymerase involved in bypass replication across sites of DNA damage and postreplicational gap-filling
  • REV1, REV3L, and MAD2L2 are pivotal proteins in translesion DNA synthesis, which allows DNA synthesis even in the presence of DNA damage
  • plays a pivotal role in mediating DNA damage-induced mutagenesis
  • is required for successful replication of G-quadruplex DNA (G4 DNA)
  • CELLULAR PROCESS nucleotide, repair
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • REV1/REV3L complex maintains genomic stability by directly participating in DSB repair in addition to the canonical TLS pathway (pMID: 21926160)
  • INTERACTION
    DNA binding to damaged DNA
    RNA
    small molecule metal binding,
  • Mg2+
  • protein
  • POLH
  • POLI
  • POLK
  • interaction with PCNA, that requires a functional BRCT domain located near the N terminus of the former protein (requirement of the BRCT domain of REV1 for cell survival and DNA damage-induced mutagenesis)
  • HSP90AA1 promotes folding of REV1 into a stable and/or functional form(s) to bind to monoubiquitinated PCNA
  • ITGA3
  • role of MAD2L2 in governing REV1 stability and interplay between translesion DNA synthesis (TLS) and anaphase-promoting complex (APC)-dependent proteolysis
  • interaction of the XRCC1-derived peptide with REV1 C-terminal domain characterized by dissociation constants in the low micromolar range
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    -
    Susceptibility to cervical carcinoma
    Variant & Polymorphism other Asn373Ser and Ser373Ser genotypes increased the risk of cervical carcinoma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS