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FLASH GENE
Symbol REPIN1 contributors: mct/pgu - updated : 13-04-2010
HGNC name replication initiator 1
HGNC id 17922
Location 7q36.1      Physical location : 150.065.878 - 150.071.133
Synonym name
  • zinc finger protein AP4
  • replication initiation region protein (60kD)
  • ATT-binding protein
  • zinc finger protein 464 (RIP60)
  • DHFR oribeta-binding protein RIP60
  • 60 kDa origin-specific DNA-binding protein
  • 60 kDa replication initiation region protein
  • Synonym symbol(s) AP4, RIP60, ZNF464, Zfp464, H_DJ0584D14.12
    DNA
    TYPE functioning gene
    STRUCTURE 5.26 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1862 7q36 KIAA1862 protein EZI 7q36.1 likely ortholog of mouse zinc finger protein EZI FLJ36112 7q36.1 hypothetical protein FLJ36112 C7orf32 7q36.1 chromosome 7 open reading frame 32 LOC389595 7 hypothetical gene supported by AK127966 MGC3036 7q31-q35 hypothetical protein MGC3036 C7orf29 7q35 chromosome 7 open reading frame 29 RARRES2 7q35 retinoic acid receptor responder (tazarotene induced) 2 LOC389596 7 LOC389596 REPIN1 7q36.1 replication initiator 1 MGC33584 7q36.1 hypothetical protein MGC33584 LOC389597 7 LOC389597 LOC389598 7 similar to expressed sequence AI854703 hIAN6 7q36.1 human immune associated nucleotide 6 LOC389599 7 similar to amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; ILP-interacting protein ILPIPA hIAN7 7q36.1 immune associated nucleotide ATQL3 7q36 antiquitin-like 3 HIMAP4 7q36.1 immunity associated protein 4 LOC392149 7 similar to transient receptor potential cation channel, subfamily C, member 6; transient receptor potential channel 6 hIAN2 7q36.1 human immune associated nucleotide 2 HIMAP2 7q36.1 immunity associated protein 2 IMAP1 7q36.1 immunity associated protein 1 IAN4L1 7q32-q36 immune associated nucleotide 4 like 1 (mouse) LOC392150 7 similar to immune associated nucleotide 4 like 1; immunity associated protein 3 LOC392151 7 similar to BET1 homolog (Golgi vesicular membrane trafficking protein p18) (hBET1) LR8 7q36.1 LR8 protein HCA112 7q36.1 hepatocellular carcinoma-associated antigen 112 ABP1 7q34-q36 amiloride binding protein 1 (amine oxidase (copper-containing)) KCNH2 7q35-q36 potassium voltage-gated channel, subfamily H (eag-related), member 2 NOS3 7q36 nitric oxide synthase 3 (endothelial cell) FLJ39415 7q36.1 hypothetical protein FLJ39415 ABCB8 7q35-q36 ATP-binding cassette, sub-family B (MDR/TAP), member 8 ACCN3 7q35 amiloride-sensitive cation channel 3, testis CDK5 7q36 cyclin-dependent kinase 5 SLC4A2 7q35-q36 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3310 63.5 567 - 2000 10606657
  • isoform 1
  • 1 - 2894 - 567 - 2000 10606657
  • isoform 1
  • 2 - 2987 - 567 - 2000 10606657
  • isoform 1
  • 3 - 3185 - 624 - 2000 10606657
  • isoform 3
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 15 C2H2 type zinc finger domains organized in three clusters termed hand Z1 (ZFs 1-5), hand Z2 (ZFs 6-8) and hand Z3 (ZFs 9-15)
  • a proline-rich region located between hands Z2 and Z3
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Repin1 (87.9pc)
    homolog to rattus Repin1 (87.9pc)
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    text
  • also located on the ribosome, the nucleus membrane
  • basic FUNCTION
  • identifying origins prior to assembly of pre-initiation complexes
  • polydactyl zinc-finger protein with weak replication enhancing activity and so far unknown cellular function
  • sequence-specific double-strand DNA-binding protein required for initiation of chromosomal DNA replication
  • facilitating DNA bending
  • may act as accessory factors in origin identification prior to the assembly of pre-initiation complexes
  • acts as a sequence-specific DNA binding protein which has a main function as accessory factor in origin identification during DNA replication
  • with geminin act as a previously undescribed repressor complex distinct from REST to negatively regulate the expression of target genes in nonneuronal cells suggesting that the REPIN1-geminin complex may contribute to suppressing the precocious expression of target genes in fetal brain
  • potential role in the regulation of adipocyte size and expression of glucose transporters SLC2A1 and SLC2A4 in adipocytes
  • has weak replication enhancing activity and may act as an accessory factor in origin identification prior to the assembly of pre-initiation complexes
  • regulates the expression of genes involved in adipogenesis, lipid droplet formation and fusion, glucose and fatty acid transport in 3T3-L1 adipocytes
  • potential role as regulator of adipocyte size and seems to be involved in the regulation of genes involved in adipogenesis, lipid droplet formation and fusion, glucose and fatty acid transport in adipocytes
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • found in a complex with RP100
  • homodimers or homomultimers
  • INTERACTION
    DNA binding to 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation within the OBR zone
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    obesity  
    potential novel target gene for anti-obesity treatment
    ANIMAL & CELL MODELS