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FLASH GENE
Symbol REM2 contributors: mct - updated : 22-03-2008
HGNC name RAS (RAD and GEM) like GTP binding 2
HGNC id 20248
Location 14q11.2      Physical location : 23.352.431 - 23.356.889
Synonym name Rad and Gem-related 2 (rat homolog)
Synonym symbol(s) FLJ38964
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1885 - 340 - Finlin (2005)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
Lymphoid/Immunespleen    
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two calcium channel beta subunit binding sites within the N-terminal 123 residues, and their interaction with the beta subunit along with membrane-targeting is required for REM2 to inhibit N-type channel activity
  • HOMOLOGY
    Homologene
    FAMILY RGK family of small GTPases
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the regulation of L-type Ca2+ channel activity and insulin secretion
  • GTPase with distinctive biochemical properties and possessing a novel cellular localization signal, consistent with its having a unique role in cell physiology
  • can promote angiogenesis and has multiple roles, such as migration, aside to proliferation alone
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein suppression of CDKN2A byREM2 places it upstream in the TP53 pathway
    cell & other
    REGULATION
    induced by strongly induced by exposure to high glucose
    Other regulated by angiogenic growth factors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS