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FLASH GENE
Symbol REG1A contributors: mct/npt - updated : 18-02-2014
HGNC name regenerating islet-derived 1 alpha
HGNC id 9951
Location 2p12      Physical location : 79.347.583 - 79.350.547
Synonym name
  • lithostathine 1 alpha
  • islet of Langerhans regenerating protein
  • islet cells regeneration factor
  • pancreatic thread protein
  • pancreatic stone protein
  • regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)
  • Synonym symbol(s) REG, PSPS1, PSP, PTP, LITA, P19, ICRF, PSPS, MGC12447
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12
    STRUCTURE 2.96 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure
  • promoter region CpG methylation was shown to regulate REG1A expression in melanoma cells
  • MAPPING cloned Y linked N status confirmed
    Map pter - REG1B - REG1A - REGL - DDEF2 - cen
    Authors Miyashita (95)
    Physical map
    DOK1 2p13 docking protein 1, 62kDa (downstream of tyrosine kinase 1) LOC130951 2p13.1 hypothetical protein BC014602 SEMA4F 2p13 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F HK2 2p13.1 hexokinase 2 POLE4 2p12 polymerase (DNA-directed), epsilon 4 (p12 subunit) TACR1 2p13-p11 tachykinin receptor 1 LOC388964 2 LOC388964 FLJ13391 2p12 hypothetical protein FLJ13391 MRPL19 2q11.1-q11.2 mitochondrial ribosomal protein L19 C2orf3 2p11.2-p11.1 chromosome 2 open reading frame 3 LOC150610 2p12 similar to Purine nucleoside phosphorylase (Inosine phosphorylase) (PNP) LRRTM4 2p12 similar to Purine nucleoside phosphorylase (Inosine phosphorylase) (PNP) HCP6 2p12 cytochrome c, somatic pseudogene UNQ429 2p12 LPPM429 REG1B 2p12 regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein) REG1A 2p12 regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein) REGL 2p12 regenerating islet-derived-like, pancreatic stone protein-like, pancreatic thread protein-like (rat) PAP 2p12 pancreatitis-associated protein CTNNA2 2p12-p11.1 catenin (cadherin-associated protein), alpha 2 LRRTM1 2p12 catenin (cadherin-associated protein), alpha 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 821 - 166 - 2000 10753861
  • a 22 aa signal peptide of 2.5 kda
  • a 144 aa mature peptide of 16.3 kda
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine    
     stomach    
    Endocrinepancreasislet of Langerhans   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, growth/childhood
    Text highly in fetal and infant brains
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C-type lectin domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Reg1 (69.6 pc)
    homolog to murine Reg1 (74.5 pc)
    Homologene
    FAMILY
  • pancreatic stone protein family, secreted proteins containing a C-type lectin domain family
  • Reg gene family, type I subclass
  • CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • mainly localized around the nucleus and at the membrane of cell bodies and neurites
  • colocalizes with exostosin tumor-like 3 (EXTL3), its putative receptor, at the membrane of these cells
  • basic FUNCTION
  • involved in positive regulation of cell proliferation (Watanabe 1990)
  • might act as an inhibitor of spontaneous calcium carbonate precipitation
  • may be associated with neuronal sprouting in brain, and with brain and pancreas regeneration
  • may act as one of the tumor promoter and contribute to the aggressive nature of pancreatic carcinoma, especially in the subpopulation with diabetes
  • plays a role in proliferation, differentiation, inflammation, and carcinogenesis of cells of the digestive system
  • plays an important role in aberrant cell proliferation and TNFSF11 expression of synovial fibroblasts, ultimately resulting in pannus formation
  • involvement of autoimmunity to REG1A, a regeneration factor, in patients with primary Sjögren's syndrome
  • plays an important role in tissue regeneration and in cell proliferation in epithelium origin tumors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may play a pivotal role in anti-apoptosis in gastric tumorigenesis under STAT3 activation
  • binds DUSP1 and regulates CCND1 in pancreatic-derived cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    highly mRNA expression in brains with Alzheimer's disease (de la Monte 1990)
    constitutional     --other  
    expressed in Barrett's esophagus (Chinuki 2008)
    constitutional     --over  
    during the very early stages of Alzheimer disease, and REG1A deposits were detected in the brain of patients with Alzheimer disease
    constitutional     --over  
    in regenerating pancreatic islets
    constitutional     --over  
    in type 1 diabetes patients and type 2 diabetic subjects with anti-REG1A antibodies in 47p100 of type 1 diabetes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • REG1A protein levels can be used as a biomarker for the diagnosis and monitoring of Celiac disease
  • Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    epigenetic regulation of the REG1A promoter region may offer a potential therapeutic approach to improve chemotherapy for metastatic melanoma patients
    immunologyinflammatory 
    restoration of normal physiological REG1α expression may contribute to rheumatoid arthritis amelioration
    ANIMAL & CELL MODELS
  • Reg1 is significantly upregulated in the liver of the 2-AAF/PH rat model, accompanied by the formation of bile ductules during liver regeneration