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FLASH GENE
Symbol REEP5 contributors: mct - updated : 06-04-2016
HGNC name receptor accessory protein 5
HGNC id 30077
Location 5q22.2      Physical location : 112.212.080 - 112.258.031
Synonym name
  • open reading frame in the MCC region
  • deleted in polyposis 1
  • polyposis coli region hypothetical protein DP1
  • TB2 protein
  • receptor expression enhancing protein 5
  • HCCR-1 binding protein deleted in polyposis 1
  • Synonym symbol(s) TB2, C5orf18, DP1, D5S346, MGC70440, YOP1, Yip2e
    DNA
    TYPE functioning gene
    STRUCTURE 45.95 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3116 - 189 - 2006 16762630
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Hearing/Equilibriumear   highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY homology to a family of ADP
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • plays a tumor-suppressor role in colon carcinogenesis
  • membrane shaping adapter protein that modulate specific G protein-coupled receptor trafficking by affecting ER cargo capacity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZFYVE27 interact with other hereditary spastic paraplegia-related proteins including myelin proteolipid protein 1 (SPG2), atlastin-1 (SPG3A), REEP1, REEP5 (similar to REEP1), KIF5A, KIF5B, KIF5C
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS