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FLASH GENE
Symbol RECK contributors: mct/npt - updated : 23-01-2017
HGNC name reversion-inducing-cysteine-rich protein with kazal motifs
HGNC id 11345
Location 9p13.3      Physical location : 36.036.909 - 36.124.451
Synonym name
  • suppression of tumorigenicity 15
  • membrane anchored glycoprotein (metastasis and invasions)
  • suppression of tumorigenicity 5
    • (reversion-inducing-cysteine-rich protein with kazal
    motifs)
    Synonym symbol(s) ST15
    DNA
    TYPE functioning gene
    STRUCTURE 87.53 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   other
    text structure 13 SNP
    MAPPING cloned Y linked N status confirmed
    Map pter - [ZBTB5 - CCL19 - FANCG FANCG - KIAA0375 - D9S1787 ] - D9S1862 - D9S1874 - qter
    Authors Gene Map (99), LDB
    Text [RECK ]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 4427 - 971 - Eisenberg (2002)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
     parathyroid   highly
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
     female systemuterus  highly
     male systemtestis  highly
     male systemprostate  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text placenta, embryonic brain, specifically expressed in Nestin-positive neural precursor cells (Muraguchi 2007)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five knot repeat
  • three kazal-like domains (K23 motif)
  • cystein rich domain
  • three protase inhibitor-like domain
  • two EGFR-like domains
  • five N-glycosylation sites
    • conjugated GlycoP , LipoP
    mono polymer heteromer , complex
    isoforms Precursor a 26 aa signal peptide of 2.5 kda, a 945 aa mature peptide of 104 kda
    HOMOLOGY
    interspecies homolog to rattus Reck (92.4 pc)
    homolog to murine Reck (93.1 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • lipid-anchor
  • GPI-anchor
    • basic FUNCTION
  • acting as a negative regulator for matrix metalloproteinase 9 and 2 (MMP9, MMP2)
  • inhibiting tumor invasion
  • acting as a serine-type endopeptidase inhibitor
  • regulates the ectodomain shedding of Notch ligands by directly inhibiting the proteolytic activity of ADAM10
  • inhibitor of ADAM10, an upstream regulator of Notch signaling and a critical modulator of brain development (Muraguchi 2007)
  • inhibits the enzymatic activities of some matrix metalloproteinases (MMP), thereby suppressing tumor cell metastasis (Takagi 2009)
  • critically regulates Notch signaling by antagonizing the ectodomain shedding of Notch ligands, which is mediated by a disintegrin and metalloproteinase domain 10 (ADAM10) (Muraguchi 2007)
  • GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK
    • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    text negative regulation of progression through cell cycle
    PATHWAY
    metabolism
    signaling
    a component
  • N-glycosylated
  • forming a complex with MT1-MMP
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MMP9 (negative regulator of MMP9 transcription) (Takagi 2009)
  • interacting with Tgat oncoprotein
  • cleaved by MMP2 and MMP7 and competitively inhibits MMP-7-catalyzed cleavage of fibronectin (Omura 2009)
  • RECK and GPR124 are part of the cell surface protein complex that transduces WNT7A- and WNT7B-specific signals in mammalian CNS endothelial cells (ECs) to promote angiogenesis and regulate the Blood-Brain Barrier
    • cell & other
    REGULATION
    inhibited by Tgat oncoprotein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    downregulation caused by promoter methylation in non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target K23 motifs of RECK protein can inhibit MMP9 secretion and activity and attenuate metastasis of lung cancer cells (Chang 2008)
    ANIMAL & CELL MODELS