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FLASH GENE
Symbol RDX contributors: mct - updated : 19-12-2017
HGNC name radixin
HGNC id 9944
Corresponding disease
DFNB24 neurosensory deafness 24
Location 11q22.3      Physical location : 110.100.167 - 110.167.437
DNA
TYPE anonymous DNA segment
STRUCTURE 121.83 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MGC33948 11q23.1 hypothetical protein MGC33948 MGC33424 11q23.1 hypothetical protein MGC33424 SLAC2-B 11q23.1 hypothetical protein MGC33424 DDX10 11q22-q23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 HCP29 11q22.3 cytochrome c, somatic pseudogene LOC260340 11q23.1 processed pseudogene mtTFA 2 LOC390249 11 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) LOC390250 11 similar to RPB5_Human KIAA1726 11q23.1 KIAA1726 protein RDX 11q22.3-q23.1 radixin FDX1 11q22.3-q23.1 ferredoxin 1 ARHGAP20 11q23.2 Rho GTPase activating protein 20 LOC120364 11q23.2 similar to Hnrpa1 protein MGC50104 11q23.2 Similar to RIKEN cDNA 1810046K07 gene LOC120376 11q23.2 hypothetical protein LOC120376 POU2AF1 11q23.1 POU domain, class 2, associating factor 1 BTG4 11q23.2-q23.3 B-cell translocation gene 4 LOC387807 11 hypothetical gene supported by AK128145; BC039505 LOC143903 11q23.2 layilin SIK2 11q23.2 salt-inducible serine/threonine kinase 2 PPP2R1B 11q23 protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform DIBD1 11q23 disrupted in bipolar affective disorder 1 C11orf1 11p15.5 chromosome 11 open reading frame 1 CRYAB 11q22.3-q23.1 crystallin, alpha B HSPB2 11q22.3-q23.1 heat shock 27kDa protein 2 MGC14839 11q23.2 similar to RIKEN cDNA 2310030G06 gene DIXDC1  DIX domain containing 1 LOC387808 11 similar to KIAA1735 protein DLAT 11q23.1 dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) LOC246731 11q23 peptidyl prolyl isomerase H (cyclophilin H) pseudogene
RNA
TRANSCRIPTS type messenger
text in the retina and inner hear
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2511 - 604 - -
8 - 1549 - 200 - -
9 - 1814 - 257 - -
16 - 2761 - 604 - -
12 - 4123 - 447 - -
14 - 4498 - 583 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Hearing/EquilibriumearinnercochleaCortihighly
Nervousbrain   highly Homo sapiens
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumskeletal  
Nervouscentralwhite matter  
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Hearing / Equilibriumstereocilia
NervousSchawnn cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal FERM (EPB41, ezrin, radixin, moesin) domain cysteine-rich, basic charged globular module with three subdomains followed by an alpha helical domain,
  • a polyproline region and
  • a C terminal autoinhibitory domain binding with inositol triphosphate
  • HOMOLOGY
    Homologene
    FAMILY ezrin/moesin/radixin-like (ERM) family member
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text highly, in the undercoat of the adherens junction
    basic FUNCTION
  • actin capping protein, involved in regulation of linkage of the cytoskeleton (actin filament) to the plasma membrane (adhesion protein)
  • responding and participating in reorganization of membrane-cytoplasmic interactions
  • ezrin, radixin and moesin are adaptor proteins that link plasma membrane receptors to the actin cytoskeleton
  • potential role for RDX in microglial activation after stroke
  • plays likely an important role in regulating P-glycoprotein (P-gp) localization and P-gp functional activity at the intestinal membrane
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    text
  • downstream effector of trafficking PRKC-integrin complex, involved in the control of cell motility
  • prominent constituent of stereocilia, participating in anchoring the pointed end of actin filaments to the membrane
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CLIC5
  • regulates cell migration and cell-cell adhesion through RAC1 (
  • P2RX7 stimulation triggers the phosphorylation of EZR/RDX/MSN, which translocate to the plasma membrane where they associate with P2RX7
  • RDX, EZR, MSN exert a redundant control on PDGFA-induced vascular smooth muscle cells (VSMC) migration by regulating focal adhesion turn-over and cell adhesion to substrate
  • GABRA5 concentrate extrasynaptically through RDX-mediated anchorage at the actin cytoskeleton
  • RHOA/ROCK1 signalling regulates an activity-dependent RDX phosphorylation switch that uncouples GABRA5 from its extrasynaptic anchor, thereby enriching synaptic receptor numbers
  • inhibition of cell adhesion by phosphorylated EZR/RDX/MSN
  • RDX is a PRG2 interaction partner and radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG2
  • cell & other
    REGULATION
    Other not sensitive to calpain
    regulated by phosphoinositides
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB24
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS