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FLASH GENE
Symbol RDX contributors: mct - updated : 19-12-2017
HGNC name radixin
HGNC id 9944
Corresponding disease
DFNB24 neurosensory deafness 24
Location 11q22.3      Physical location : 110.100.167 - 110.167.437
DNA
TYPE anonymous DNA segment
STRUCTURE 121.83 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text in the retina and inner hear
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2511 - 604 - -
8 - 1549 - 200 - -
9 - 1814 - 257 - -
16 - 2761 - 604 - -
12 - 4123 - 447 - -
14 - 4498 - 583 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Hearing/EquilibriumearinnercochleaCortihighly
Nervousbrain   highly Homo sapiens
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumskeletal  
Nervouscentralwhite matter  
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Hearing / Equilibriumstereocilia
NervousSchawnn cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal FERM (EPB41, ezrin, radixin, moesin) domain cysteine-rich, basic charged globular module with three subdomains followed by an alpha helical domain,
  • a polyproline region and
  • a C terminal autoinhibitory domain binding with inositol triphosphate
  • HOMOLOGY
    Homologene
    FAMILY ezrin/moesin/radixin-like (ERM) family member
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text highly, in the undercoat of the adherens junction
    basic FUNCTION
  • actin capping protein, involved in regulation of linkage of the cytoskeleton (actin filament) to the plasma membrane (adhesion protein)
  • responding and participating in reorganization of membrane-cytoplasmic interactions
  • ezrin, radixin and moesin are adaptor proteins that link plasma membrane receptors to the actin cytoskeleton
  • potential role for RDX in microglial activation after stroke
  • plays likely an important role in regulating P-glycoprotein (P-gp) localization and P-gp functional activity at the intestinal membrane
  • supportive role of EZR, RDX, MSN in cortical activities during cytokinesis
  • ERM proteins, EZR, radixin and moesin, assist in the formation and maintenance of specialized plasma membrane structures and membrane vesicle structures
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    text
  • downstream effector of trafficking PRKC-integrin complex, involved in the control of cell motility
  • prominent constituent of stereocilia, participating in anchoring the pointed end of actin filaments to the membrane
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CLIC5
  • regulates cell migration and cell-cell adhesion through RAC1 (
  • P2RX7 stimulation triggers the phosphorylation of EZR/RDX/MSN, which translocate to the plasma membrane where they associate with P2RX7
  • RDX, EZR, MSN exert a redundant control on PDGFA-induced vascular smooth muscle cells (VSMC) migration by regulating focal adhesion turn-over and cell adhesion to substrate
  • GABRA5 concentrate extrasynaptically through RDX-mediated anchorage at the actin cytoskeleton
  • RHOA/ROCK1 signalling regulates an activity-dependent RDX phosphorylation switch that uncouples GABRA5 from its extrasynaptic anchor, thereby enriching synaptic receptor numbers
  • inhibition of cell adhesion by phosphorylated EZR/RDX/MSN
  • RDX is a PRG2 interaction partner and radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG2
  • cell & other
    REGULATION
    Other not sensitive to calpain
    regulated by phosphoinositides
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB24
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS