| basic FUNCTION
| short chain alcohol dehydrogenase activity |
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involved in metabolims of short chain aldehydes |
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may be the key enzyme in formation of 11-cis-retinal during regeneration of the cone visual pigments |
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disrupting the cycling of vitamin A analogs between the photoreceptor cells and the adjacent retinal pigment epithelium |
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reduces dihydrotestosterone to androstanediol, and is thus also involved in steroid metabolism  |
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potntial critical function is the reduction of all-trans-retinal that exceeds the reductive capacity of the photoreceptor outer segments |
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RDH12-but not RDH11-also protected against light-induced apoptosis of photoreceptors |
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with RDH11, can enzymatically reduce toxic lipid peroxidation products such as 4-hydroxynonenal (4-HNE) |
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by detoxifying stray retinal, RDH12 acts as a barrier against intracellular aldehyde diffusion |
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RDH12 function in the photoreceptor inner segments is key, because loss of function mutations cause retinal degeneration in some forms of Leber congenital amaurosis |
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can reduce all-trans-retinal that enters the inner segment from the outer segment or from the environment outside the cell |
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RDH12, RDH8, both enzymes are required to reduce all-trans-retinal generated after bleaching and present in both photoreceptor inner and outer segments |
