basic FUNCTION
| photoreceptor-specific calcium binding protein, involved in recovery to the dark state |
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may be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin |
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prevents premature phosphorylation of rhodopsin until the opening of cGMP-gated ion channels causes a decrease in intracellular calcium levels, signaling completion of the light response |
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in photoreceptor outer segments, recoverin is involved into the recovery of visual cycle via Ca(2+)-dependent interaction with disk membranes and inhibition of GRK1 |
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RCVRN potentiates the sensitivity of cones in dim light conditions but does not contribute to their capacity to function in bright light |
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is the first retina-specific photoreceptor protein that was shown to undergo aberrant expression, due to its promoter demethylation, as a cancer-retina antigen in a number of malignant tumors |
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potential involvement of thiol oxidation of recoverin in triggering of photoreceptor cell damage/death mechanisms |
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is one of a few photoreceptor proteins demonstrating thiol oxidation in response to moderate doses of light illumination |