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FLASH GENE
Symbol RCOR3 contributors: mct - updated : 15-11-2014
HGNC name REST corepressor 3
HGNC id 25594
Location 1q32.3      Physical location : 211.432.707 - 211.489.723
Synonym symbol(s) FLJ10876, CoREST3
DNA
TYPE functioning gene
STRUCTURE 57.02 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 4474 - 553 - -
11 - 4232 - 436 - -
11 - 1873 - 449 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
 vessel   highly
Lymphoid/Immunelymph node   highly
Nervousbrain     Rattus norvegicus
Reproductivefemale systemovary  highly
 male systemtestis  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Rcor3
intraspecies paralog to RCOR1, RCOR2
Homologene
FAMILY
CATEGORY regulatory , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • involved in the regulation of transcription, DNA-dependent
  • RCOR3 is a natural inhibitor of KDM1A, suggesting a dual mechanism of regulating the enzymatic activity and restraining the epigenetic impact of this robust demethylase during hematopoietic differentiation
  • actions of RCOR2 and RCOR3, in regulating KDM1A enzymatic activity and biological function in hematopoietic cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • whereas RCOR2, like RCOR1, facilitates KDM1A-mediated nucleosomal demethylation, RRCOR3 competitively inhibits this process
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker might be a potential biomarker for the outcome of patients with hepatitis B
    Therapy target
    ANIMAL & CELL MODELS