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FLASH GENE
Symbol RCOR2 contributors: mct - updated : 15-11-2014
HGNC name REST corepressor 2
HGNC id 27455
Location 11q13.1      Physical location : 63.678.693 - 63.684.316
Synonym symbol(s) CoREST2, CoREST
DNA
TYPE functioning gene
STRUCTURE 5.71 kb
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2521 - 523 - 2011 21433225
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Rattus norvegicus
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nonconserved leucine in the first SANT domain severely weakens its association with HDAC1/2
    • HOMOLOGY
    intraspecies paralog to RCOR1, RCOR3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • RCOR1, RCOR2 have largely independent and previously uncharacterized roles in promoting neural stem cells (NSCs) multilineage potential and modulating early neural fate decisions
  • is predominantly expressed in ESCs and forms a complex with KDM1A and facilitates its nucleosomal demethylation activity
  • RCOR2/KDM1A control the development of pyramidal cortical neurons
  • actions of RCOR2 and RCOR3, in regulating KDM1A enzymatic activity and biological function in hematopoietic cells
  • may be a key regulator of inflammaging (
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • KDM1A is associated with RCOR2 in the KDM1A–RCOR2 corepressor complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interplay between HMG20B and HMG20A controls the activity of the KDM1A–RCOR2 complex during neuronal differentiation
  • displays lower interaction with HDAC1/2, which is barely present in KDM1A-RCOR2 complexes
  • whereas RCOR2, like RCOR1, facilitates KDM1A-mediated nucleosomal demethylation, RRCOR3 competitively inhibits this process
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS