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FLASH GENE
Symbol RCAN3 contributors: mct/npt - updated : 22-02-2008
HGNC name RCAN family member 3
HGNC id 3042
Location 1p36.11      Physical location : 24.829.386 - 24.862.425
Synonym name
  • calcipressin 3
  • regulator of calcineurin (RCAN) 3 protein
  • myocyte-enriched calcineurin interacting protein 3
  • regulator of calcineurin 3
  • Down syndrome critical region gene 1-like 2
  • Synonym symbol(s) MCIP3, CCP3, RCN3, DSCR1L2, MCIP3, hRCN3
    DNA
    TYPE functioning gene
    STRUCTURE 33.04 kb     5 Exon(s)
    regulatory sequence
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1700 - 241 - Facchin (2008)
    - - 658 - 183 - Facchin (2008)
    lacks exons 1 and 3
    - - 667 - 173 - Facchin (2008)
    lacks exons 1and 4
    - - 382 - 115 - Facchin (2008)
    lacks exons 1,3,4
    - - 720 - 212 - Facchin (2008)
    lacks exon 1
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine   
     liver   highly
    Lymphoid/Immunespleen    
     thymus    
    Nervousbrain    
    Reproductivefemale systemplacenta   
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines Burkitt lymphoma cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal positively charged and aromatic AA with RNA recognition motif (RNA-binding protein)
  • a serine-proline motif (the FLISPP signature of the family) including an ISPP XSPP box
  • a Cn-inhibitor RCAN (CIC) and the PxIxxT motifs (Mulero 2007)
  • secondary structure beta/alpha
    HOMOLOGY
    interspecies homolog to murine Dscr1l2 (90.4pc)
    homolog to rattus Dscr1l2 (90.4pc)
    intraspecies paralog to RCAN2
    paralog to RCAN1
    Homologene
    FAMILY
  • DSCR1-like family
  • RCAN family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • inhibiting calcineurin-dependent transcriptional responses and playing a role during central nervous system development
  • may be involved in cardiac contraction
  • playing a role in inhibiting Cn activity (Mulero 2007)
  • down-regulates NFAT-dependent cytokine gene expression (Mulero 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with cardiac troponin I (TNNI3)
  • interacts physically and functionally with calcineurin This interaction through the CIC motif (Mulero 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS