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FLASH GENE
Symbol RCAN2 contributors: mct - updated : 22-02-2008
HGNC name regulator of calcineurin 2
HGNC id 3041
Location 6p12.3      Physical location : 46.188.468 - 46.293.531
Synonym name
  • Down syndrome candidate region 1-like 1
  • thyroid hormone-responsive (skin fibroblasts)
  • Down syndrome critical region gene 1-like 1
  • Synonym symbol(s) DSCRL1, ZAKI4, MCIP2, CSP2, MCIP2, hRCN2, ZAKI-4, DSCR1L1
    DNA
    TYPE like-sequence
    STRUCTURE 104.00 kb     4 Exon(s)
    regulatory sequence
    MAPPING cloned Y linked N status confirmed
    Map pter - D6S1616 - D6S1582 - D6S1650 - DSCR1L1 - D6S1651 - D6S542 - D6S438 - D6S427 - cen
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    text with two alternatively spliced mRNA speckles
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - polyA site 3400 21 192 only in brain Miyazaki,Cao
    suggested to inhibit calcineurin activity
    - splicing polyA site 3240 - 243 ubiquitous and abundantly in heart, brain, liver Cao
    suggested to inhibit calcineurin activity
    - - polyA site 1400 - 192 dominant in liver -
    - splicing 3253 - 243 ubiquitous ,abundantly in heart, brain, liver,muscle Cao
    suggested to inhibit calcineurin activity
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrineparathyroid   highly
    Nervousbrain   highly
     nerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal RNA recognition motif (RNA-binding protein)
  • a short unique serine-proline motif (the FLISPP signature of the family) including an ISPP XSPP box
  • a Cn-inhibitor RCAN (CIC) and the PxIxxT motifs (Mulero 2007)
  • bind and inhibit Calcineurin through the C-terminal region (Mulero 2007)
  • secondary structure beta/alpha
    HOMOLOGY
    interspecies ortholog to hamster Adapt 78
    homolog to Drosophila melanogaster
    homolog to C.elegans
    homolog to yeast S.pombe
    homolog to yeast S.cerevisiae
    intraspecies paralog to RCAN1, DSCR1L2
    Homologene
    FAMILY MCIP family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • putative regulator of calcineurin-mediated signaling pathway
  • potently activates angiogenesis and could be an attractive target for antiangiogenesis therapy
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein calcineurin A, PPP3CA, PPP3CB, PPP3CC
    cell & other
    REGULATION
    induced by thyroid hormone-responsive gene,triiodothyronine (T3)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    induced the proliferation and activation of the transcription factor NFAT in cultured endothelial cells and promoted angiogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target attractive target for antiangiogenesis therapy
    ANIMAL & CELL MODELS