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FLASH GENE
Symbol RC3H2 contributors: mct - updated : 04-09-2013
HGNC name ring finger and CCCH-type zinc finger domains 2
HGNC id 21461
Location 9q33.2      Physical location : 125.611.731 - 125.667.562
Synonym name
  • membrane-associated nucleic acid binding protein
  • membrane associated DNA binding protein
  • RING finger protein 164
  • Roquin 2
  • Synonym symbol(s) MNAB, FLJ20301, FLJ20713, RNF164, MGC52176
    DNA
    TYPE functioning gene
    STRUCTURE 60.73 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3991 132 1191 - 2013 23583642
    18 - 3581 - 1064 - 2013 23583642
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • NH2 terminal C3HC4 RING finger
  • CCCH-type zinc finger domain
  • C terminal transmembrane domain
  • HOMOLOGY
    Homologene
    FAMILY
  • zinc finger proteins family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • binding and internalization of extracelular DNA
  • RC3H1, RC3H2 maintain tolerance by preventing inappropriate T cell activation and Tfh cell differentiation, and RC3H2 compensates in the absence of RC3H1, but not in the presence of its mutated form
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • RC3H2 shares functions with its paralog RC3H11 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS