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FLASH GENE
Symbol RBPMS contributors: shn/npt/mct - updated : 02-03-2017
HGNC name RNA binding protein with multiple splicing
HGNC id 19097
Location 8p12      Physical location : 30.241.943 - 30.429.734
Synonym name
  • RNA-binding protein with multiple splicing
  • heart and RRM expressed sequence
  • Synonym symbol(s) HERMES, FLJ32971, RBP-MS, RBPMS1
    DNA
    TYPE functioning gene
    STRUCTURE 187.79 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D8S1820 - D8S1809 - RBPMS - D8S540 - D8S1770 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1438 - 219 - 2006 17099224
    9 splicing 2948 - 196 - 2006 17099224
    10 splicing 3034 - 204 - 2006 17099224
    10 splicing 3154 - 196 - 2006 17099224
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Digestiveintestinesmall intestine  highly
     intestinelarge intestinecolon highly
    Reproductivefemale systemovary  highly
     male systemprostate  highly
    Visualeyeretina  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivecartilage    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroblast Homo sapiens
    not specificchondrocyte Homo sapiens
    Visualganglion cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RRM domain at the N-terminus containing two short stretches of conserved sequence RNP1 and RNP2 and a few highly conserved hydrophobic residues, a single RNA recognition motif (RRM)
  • HOMOLOGY
    interspecies ortholog to Rbpms, Mus musculus
    ortholog to RBPMS, Pan troglodytes
    Homologene
    FAMILY
  • RRM family of RNA-binding proteins
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm
    text
  • translocates in granules from retinal ganglion cells (RGCs) bodies down the growing axons
  • basic FUNCTION
  • role in regulation of Smad-mediated transcriptional activity (Sun et al, 2006)
  • a marker for retinal ganglion cells
  • regulates a variety of RNA processes, including pre-mRNA splicing, RNA transport, localization, translation, and stability
  • is likely a critical repressor of JUN signaling
  • involved in mRNA transport, localization and stability, with key roles in axon guidance, smooth muscle plasticity, as well as regulation of cancer cell proliferation and migration
  • functions likely as part of a RNP complex in the nucleus that facilitates selection of germline RNAs for germ plasm localization
  • potential role in the maintenance of normal articular cartilage
  • is a regulator of erythropoiesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    RNA metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is known to physically interact with SMAD2, SMAD3, and SMAD4 and stimulate smad-mediated transactivation through enhanced SMAD2 and SMAD3 phosphorylation and associated promotion of nuclear accumulation of Smad proteins
  • TGF-beta receptor type I, TbetaR-I (Sun et al, 2006)
  • ataxin 1, ATXN1 (Lim et al, 2006)
  • physically and functionally interacts with JUN
  • although NONO and SFPQ are nuclear paraspeckle components, these proteins formed cytoplasmic granules with RBPMS in the neurites
  • ERG is recruited to mRNAs via interaction with RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex
  • physically interact with Smads and enhance TGFB1-mediated SMAD2/3 transcriptional activity in mammalian cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    RBPMS activation may be a useful strategy for cancer treatment
    ANIMAL & CELL MODELS