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FLASH GENE
Symbol RBP4 contributors: mct - updated : 07-12-2011
HGNC name retinol binding protein 4, plasma
HGNC id 9922
Corresponding disease
RBP4 night blindness and progressive atrophy of the retinal pigment epithelium
Location 10q23.33      Physical location : 95.351.593 - 95.360.993
Synonym name retinol-binding protein 4, interstitial
Synonym symbol(s) RBP, PRBP
DNA
TYPE functioning gene
STRUCTURE 9.40 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 941 - 201 - 2005 16156801
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Endocrinepancreas    
Reproductivefemale systembreastmammary gland  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cells
SystemCellPubmedSpeciesStageRna symbol
not specificadipocyte
cell lineage
cell lines
fluid/secretion serum
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer monomer
HOMOLOGY
Homologene
FAMILY
  • calycin superfamily
  • lipocalin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • delivery of retinol from the liver stores to peripheral tissues
  • adipocyte-derived 'signal' that may contribute to the pathogenesis of type 2 diabetes
  • adipokine, linking glucose uptake in adipocytes with systemic insulin sensitivity
  • secreted by adipocytes, and associated with insulin resistance
  • adipocytokine that may link obesity and insulin resistance
  • RBP4 secretion was restricted to mature adipocytes, further indicating that RBP4 is strongly related to differentiation of adipocytes
  • has a robust acute effect of enhancement of NO production via stimulation of part of the PI3K/Akt/eNOS pathway and inhibition of ERK1/2 phosphorylation which results in vasodilatation
  • RBP4 and its membrane receptor STRA6 coordinate cellular retinol uptake
  • retinol-dependent metabolic function of RBP4 that may have important implications for the treatment of obesity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cell to cell transport
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • complexing with transthyretin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • retinol binding
  • transthyretin binding prevents its loss by glumerular filtration
  • cell & other
    REGULATION
    Other variants of RBP4 putatively influence the age of onset of familial amyloid polyneuropathy
    ASSOCIATED DISORDERS
    corresponding disease(s) RBP4
    related resource Retinal Information Network
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in type 2 diabetes
    tumoral     --low  
    silencing by methylation in esophageal squamous cell carcinoma
    constitutional     --low  
    maternal and umbilical cord serum RBP4 levels were lower in patients with preeclampsia than in normal pregnant women in the third trimester of pregnancy
    constitutional     --low  
    in familial partial lipodystrophy
    Susceptibility
    Variant & Polymorphism
    Candidate gene lowering RBP4 is a new strategy for treating tye 2 diabetes
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    lowering RBP4 is a new strategy for treating tye 2 diabetes
    obesity  
    retinol-dependent metabolic function of RBP4 that may have important implications for the treatment of obesity
    ANIMAL & CELL MODELS