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FLASH GENE
Symbol RBMX contributors: mct/npt - updated : 09-10-2017
HGNC name RNA binding motif protein, X chromosome
HGNC id 9910
Corresponding disease
Location Xq26.3      Physical location : 135.951.352 - 135.962.939
Synonym name
  • glycoprotein p43
  • heterogeneous nuclear ribonucleoprotein G
  • Synonym symbol(s) HNRPG, huRNPG, RBMXP1, RBMXRT, RNMX, hnRNP-G
    DNA
    TYPE functioning gene
    STRUCTURE 11.59 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located previously mapped to chromosome 6 (see RBMXP1)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2097 43 391 - 2008 18445477
    8 - 2071 - 196 - 2008 18445477
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveesophagus   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrain   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N- terminal RNA recognition motif (RRM)
  • a domain, centrally positioned, and consisting of AAs 186-236 that acts autonomously and thus is named NTD for nascent transcripts targeting domain
  • a new auxiliary RNA binding domain (RBD)(a short region of 58 AAs positioned at the C- terminal end of the protein, which recognizes an RNA motif predicted to adopt an hairpin structure
  • a C terminal glycine-rich domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to paralog to RBMY (on chromosome X)
    Homologene
    FAMILY
  • RBMY family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,euchromosome
    text in the spliceosome
    basic FUNCTION
  • nucleic acid-binding protein that have critical roles in DNA repair, telomere regulation, and transcriptional gene regulation
  • having tumor-suppressive activity in squamous cell carcinoma cells
  • heterogeneous nuclear ribonucleoprotein that has a role in alternative splicing
  • plays an essential role in chromosome morphogenesis through its association with chromatin, but not with RNA
  • is likely a cohesion regulator that maintains the proper cohesion of sister chromatids
  • playing a role in the regulation of TNFRSF1A release pathways
  • might play a significant role in the degenerative process of retinal ganglion cells (RGCs) after light-induced damage in the retina
  • is involved in the maintenance of the structure of the virus factory in the nucleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • core protein G component of heterogeneous nuclear RNA ribonucleoprotein complex
  • complex SFRS10/RBMX and SMN2 exon 7 RNA
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • SFRS10 (to facilitates SMN exon 7 inclusion
  • interacting with TXNIP (promotes the expression of TXNIP and mediates its tumor-suppressive effect)
  • ERAP1-associated protein that regulates both the constitutive release of TNFRSF1A exosome-like vesicles and the inducible proteolytic cleavage of TNFRSF1A ectodomains
  • interacting with SAFB (major role in the activation of SREBF1 through its interaction with RBMX)(Omura 2009)
  • RBMX accumulated at DNA lesions through multiple domains in a poly(ADP-ribose) polymerase 1-dependent manner and promoted homologous recombination (HR) by facilitating proper BRCA2 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRXS11
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrant expression of RBMX occurring during oral carcinogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be useful markers for the early detection of human oral cancer
  • Therapy target
    ANIMAL & CELL MODELS