Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RBMS3 contributors: mct - updated : 23-01-2013
HGNC name RNA binding motif, single stranded interacting protein
HGNC id 13427
Location 3p24.1      Physical location : 29.322.802 - 30.051.886
DNA
TYPE functioning gene
STRUCTURE 729.08 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391522 3 similar to Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP) NGLY1 3p24.1 N-glycanase 1 LOC246135 3p24.1 TBP-associated factor 9-like pseudogene FLJ12409 3p24.1 hypothetical protein FLJ12409 FLJ20604 3p24.1 hypothetical protein FLJ20604 LOC285326 3p24.1 hypothetical protein LOC285326 LOC391523 3 similar to Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-3-epimerase) (HUSSY-17) VENTX2P4 3p24.1 VENT-like homeobox 2 pseudogene 4 LRP15 3p24 hypothetical protein LRP15 FLJ32685 3p24.1 hypothetical protein FLJ32685 SLC4A7 3p22 solute carrier family 4, sodium bicarbonate cotransporter, member 7 LOC285321 3p23 similar to tropomyosin 4 EOMES 3p21.3-p21.2 eomesodermin homolog (Xenopus laevis) MGC61571 3p23 hypothetical protein MGC61571 AZ2 3p23 5-azacytidine induced gene 2 LOC152098 3p23 hypothetical protein LOC152098 FLJ33651 3p23 hypothetical protein FLJ33651 LOC131572 3p23 similar to MEST LOC389100 3 LOC389100 RBMS3 3p24.3-p23 RNA binding motif, single stranded interacting protein TGFBR2 3p22 transforming growth factor, beta receptor II (70/80kDa) LOC339896 3p23-p22.3 hypothetical protein LOC339896 LOC339897 3p22.3 similar to calponin 2; Calonin 2 LOC391524 3 similar to Thyroid hormone receptor-associated protein complex 150 kDa component (Trap150) SIMP 3p22.3 source of immunodominant MHC-associated peptides OSBPL10 3p22.3 oxysterol binding protein-like 10 LOC344787 3p22.3 similar to KIAA2033 protein KIAA0089 3p22.3 similar to KIAA2033 protein LOC391525 3 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) CKLFSF8 3p22.3 chemokine-like factor super family 8 CKLFSF7 3p22.3 chemokine-like factor super family 7 CKLFSF6 3p22.3 chemokine-like factor super family 6 LOC285260 3p22.3 similar to ribosomal protein L31 DNCLI1 3p22.2 dynein, cytoplasmic, light intermediate polypeptide 1 LOC391526 3 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) CNOT10 3p22.3 CCR4-NOT transcription complex, subunit 10
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 8234 - 434 - 2003 13679028
13 - 1740 - 420 - 2003 13679028
14 - 8186 - 421 - 2003 13679028
14 - 8180 - 419 - 2003 13679028
14 - 1779 - 433 - 2003 13679028
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver, cochlea
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two RNA binding motifs
HOMOLOGY
Homologene
FAMILY
CATEGORY RNA associated , transcription factor , tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • key regulator of profibrotic potential of HSCs (Hepatic stellate cells), representing a novel mechanism by which activated HSCs contribute to liver fibrosis
  • tumor suppression function in esophageal squamous cell carcinoma (ESCC), acting through MYC downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease
  • had a pro-apoptotic role in a mitochondrial-dependent manner via activation of caspase-9 and PARP1
  • function for RBMS3 as an important tumor suppressor gene in nasopharyngeal carcinoma
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • by binding PRRX1 mRNA in a sequence-specific manner, controls PRRX1 expression and indirectly collagen synthesis
  • inhibited microvessel formation, which may be mediated by down-regulation of MMP2 and CTNNB1 and inactivation of its downstream targets, including CCND1, MYC, MMP7, and MMP9
  • interaction between RBMS3 and ZNF516 influences bone mineral density
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in nasopharyngeal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS