Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RBM5 contributors: mct - updated : 30-10-2017
HGNC name RNA binding motif protein 5
HGNC id 9902
Location 3p21.3      Physical location : 50.126.367 - 50.156.390
Synonym symbol(s) LUCA15, G15, H37, FLJ39876
DNA
TYPE functioning gene
STRUCTURE 30.00 kb     25 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map see SEMA3F
Physical map
GMPPB 3p21.31 GDP-mannose pyrophosphorylase B IHPK1 3p21.31 inositol hexaphosphate kinase 1 LOC389117 3 similar to mouse fat 1 cadherin LOC389118 3 similar to VLLR9392 LOC389119 3 similar to RIKEN cDNA 6530418L21 UBE1L 3p21.2 ubiquitin-activating enzyme E1-like TRIP 3p21.31 TRAF interacting protein MGC8407 3p21.31 hypothetical protein MGC8407 LOC389120 3 similar to RIKEN cDNA 4921517D21 LOC285405 3p21.31 similar to RIKEN cDNA 4921517D21 MST1R 3p21.3 macrophage stimulating 1 receptor (c-met-related tyrosine kinase) MGC13272 3p21.31 hypothetical protein MGC13272 RBM6 3p21.3 RNA binding motif protein 6 RBM5 3p21.3 RNA binding motif protein 5 SEMA3F 3p21.31 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F GNAT1 3p21.2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 SLC38A3 3p21.3 solute carrier family 38, member 3 GNAI2 3p21.31 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 SEMA3B 3p21.3 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B FLJ38608 3p21.31 hypothetical protein FLJ38608 IFRD2 3p21.3 interferon-related developmental regulator 2 HYAL3 3p21.3 hyaluronoglucosaminidase 3 FUS2 3p21.3 putative tumor suppressor HYAL1 3p21.3 hyaluronoglucosaminidase 1
regionally located located in a region duplicated from the Xp11.3-p11.23 region, containing UBE1 and DXS8237E, in the TSG3B region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 3135 - 815 - Shu (2007)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 mouth   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal region, with two RNA binding motifs (RNP1) flanking a C2C2 zinc finger motif and
  • in the C terminal region, a C2H2 zinc finger motif and a bipartite nuclear localization signal (NLS)
  • HOMOLOGY
    intraspecies homolog to DXS8237E
    Homologene
    FAMILY
    CATEGORY DNA associated , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the control of apoptosis
  • may mediate apoptosis in a TP53-independent manner, acting as a post-transcriptional regulator for cell cycle/apoptotic-related proteins
  • nuclear SR-related RNA binding protein with the ability to modulate both apoptosis and the cell cycle, and retard tumour formation
  • regulates CASP2 alternative splicing and promotes the formation of proapoptotic CASP-2L isoform
  • having a role as an apoptosis regulator in cancer cells
  • functions as an alternative splicing regulator of apoptosis-related genes
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein binds to CASP2 pre-mRNA
    cell & other
    REGULATION
    Other regulated by reversible phosphorylation (mechanism capable of regulating RBM5 participation in modulating apoptosis, and perhaps tumour suppression)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS