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FLASH GENE
Symbol RBM39 contributors: mct - updated : 26-01-2013
HGNC name RNA binding motif protein 39
HGNC id 15923
Location 20q11.23      Physical location : 34.291.531 - 34.330.193
Synonym name
  • coactivator of activating protein 1 and estrogen receptors
  • RNA-binding region (RNP1, RRM) containing 2
  • hepatocellular carcinoma protein 1
  • splicing factor CC1.3
  • Synonym symbol(s) HCC1, CAPER, CC1.3, RNPC2, FLJ44170, DKFZp781C0423, Caper alpha
    DNA
    TYPE functioning gene
    STRUCTURE 38.72 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2881 59 530 - 2002 11704680
    17 - 2863 - 524 - 2002 11704680
    16 - 2797 - 502 - 2002 11704680
    16 - 2815 - 508 - 2002 11704680
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Endocrinethyroid    
    Nervousbrain    
    Reproductivefemale systemovary   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three RNA recognition motif
  • HOMOLOGY
    interspecies homolog to murine Rnpc2
    Homologene
    FAMILY
  • splicing factor SR family
  • U2AF65 family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • concentrated in nuclear speckles
  • colocalizes with the core spliceosomal snRNP proteins
  • basic FUNCTION
  • containing motifs characteristic of splicing factors
  • coactivator of activating protein and estrogen receptors
  • RBM23 and RBM39 regulate both steroid hormone receptor-mediated transcription and alternative splicing
  • new transcriptional coregulator for REL and reveals an important role in modulating REL oncogenic activity
  • mediates alternative splicing and controls the shift from VEGFA(189) to VEGFA(165), found in Ewing sarcoma cells
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with NCOA6
  • alternative splicing functions of PCBP1 mediated by its intrinsic interaction with RBM39, a U2 snRNP auxiliary factor-related protein previously implicated in RNA splicing
  • interacting wth U2AF2
  • IGF2BP1 and RBM39 shifted the splicing ratio of ISCU toward the incorrect splice form, enhancing myopathy with lactic acidosis
  • BMP4-dependent transcription is negatively autoregulated in part by SIN3B alternative splicing, and RBM39 plays a role in this process
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS