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FLASH GENE

Symbol

RBM38

contributors: mct/pgu - updated : 06-06-2015

HGNC name	RNA binding motif protein 38
HGNC id	15818

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q13.31      Physical location : 55.966.462 - 55.984.384
Synonym name	RNA-binding region (RNP1, RRM) containing 1
	ssDNA-binding protein SEB4
	CLL-associated antigen KW-5
	RNA-binding region containing protein 1
	RNA-binding protein 38
Synonym symbol(s)	SEB4D, SEB4B, HSRNASEB, dJ800J21.2, RNPC1, SEB4

DNA

TYPE	functioning gene
STRUCTURE	17.93 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017495 4 - 2401 NP_059965 - 239 - 2006 17050675 isoform a, RNPC1a induces cell cycle arrest in G1, although both isoforms are expressed in the nucleus and cytoplasm able to stabilize both the basal and stress-induced CDKN1A transcripts required to maintain the stability of CDKN1A transcript induced by TP53 NM_183425 3 - 2346 NP_906270 - 121 - 2006 17050675 isoform b, RNPC1b expressed in the nucleus and cytoplasm and both isoforms directly bind to the 3' untranslated region in CDKN1A transcript

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Lymphoid/Immune tonsils       highly Reproductive female system ovary     highly   male system prostate     highly Respiratory lung         Visual eye uvea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a RRM domain required for binding, and regulating the stability of, TP63 transcript

HOMOLOGY

interspecies	homolog to murine Rbm38 (95.4pc)
	homolog to rattus Rbm38 (94.9pc)

Homologene

FAMILY

RBM38 family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	RNA-binding protein and target of the TP53 family, required for maintaining the stability of the basal and stress-induced CDKN1A transcript
	RNA-binding protein and a target of the TP53 family, regulating TP63 mRNA stability and consequently TP63 activity
	modulates the RNA binding activity of ELAVL1 and cooperates with it to regulate CDKN1A mRNA stability
	promotes keratinocyte differentiation by repressing TP63 expression
	plays a crucial role in cell cycle arrest and myogenic differentiation via its binding to CDKN1A
	plays potentially a role in tumorigenesis by repressing TP53 translation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA	can bind AU-rich elements in CDKN1A 3'UTR

small molecule

protein	plays a crucial role in cell cycle arrest and myogenic differentiation via its binding to CDKN1A
	TP53 target and a RNA-binding protein, that is a critical regulator of TP53 translation
	ELAVL1 is a target of RBM38 and a mediator of RBM38-induced growth suppression and facilitates RBM38-mediated growth suppression by repressing MYC expression
	RBM38 is a target of TP73, the mutual regulation between TP73 and RBM38 constitutes a novel feed-forward loop, which might be explored as a target for tumors without a functional TP53
	GDF15 can be regulated through RBM38 via mRNA stability
	ERBB2, MYC, WIF1, RBM38, PTEN, are involved in the HOTAIR regulation network

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   led to significant G&8320;/G&8321; cell cycle accumulation and significantly enhanced cellular resistance to radiation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     may represent a potential therapeutic target for enhancing tumor sensitivity to radiation

ANIMAL & CELL MODELS