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FLASH GENE
Symbol RBM38 contributors: mct/pgu - updated : 06-06-2015
HGNC name RNA binding motif protein 38
HGNC id 15818
Location 20q13.31      Physical location : 55.966.462 - 55.984.384
Synonym name
  • RNA-binding region (RNP1, RRM) containing 1
  • ssDNA-binding protein SEB4
  • CLL-associated antigen KW-5
  • RNA-binding region containing protein 1
  • RNA-binding protein 38
  • Synonym symbol(s) SEB4D, SEB4B, HSRNASEB, dJ800J21.2, RNPC1, SEB4
    DNA
    TYPE functioning gene
    STRUCTURE 17.93 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2401 - 239 - 2006 17050675
  • isoform a, RNPC1a
  • induces cell cycle arrest in G1, although both isoforms are expressed in the nucleus and cytoplasm
  • able to stabilize both the basal and stress-induced CDKN1A transcripts
  • required to maintain the stability of CDKN1A transcript induced by TP53
  • 3 - 2346 - 121 - 2006 17050675
  • isoform b, RNPC1b
  • expressed in the nucleus and cytoplasm and both isoforms directly bind to the 3' untranslated region in CDKN1A transcript
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemovary  highly
     male systemprostate  highly
    Respiratorylung    
    Visualeyeuvea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RRM domain required for binding, and regulating the stability of, TP63 transcript
  • HOMOLOGY
    interspecies homolog to murine Rbm38 (95.4pc)
    homolog to rattus Rbm38 (94.9pc)
    Homologene
    FAMILY
  • RBM38 family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • RNA-binding protein and target of the TP53 family, required for maintaining the stability of the basal and stress-induced CDKN1A transcript
  • RNA-binding protein and a target of the TP53 family, regulating TP63 mRNA stability and consequently TP63 activity
  • modulates the RNA binding activity of ELAVL1 and cooperates with it to regulate CDKN1A mRNA stability
  • promotes keratinocyte differentiation by repressing TP63 expression
  • plays a crucial role in cell cycle arrest and myogenic differentiation via its binding to CDKN1A
  • plays potentially a role in tumorigenesis by repressing TP53 translation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA can bind AU-rich elements in CDKN1A 3'UTR
    small molecule
    protein
  • plays a crucial role in cell cycle arrest and myogenic differentiation via its binding to CDKN1A
  • TP53 target and a RNA-binding protein, that is a critical regulator of TP53 translation
  • ELAVL1 is a target of RBM38 and a mediator of RBM38-induced growth suppression and facilitates RBM38-mediated growth suppression by repressing MYC expression
  • RBM38 is a target of TP73, the mutual regulation between TP73 and RBM38 constitutes a novel feed-forward loop, which might be explored as a target for tumors without a functional TP53
  • GDF15 can be regulated through RBM38 via mRNA stability
  • ERBB2, MYC, WIF1, RBM38, PTEN, are involved in the HOTAIR regulation network
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    led to significant G&8320;/G&8321; cell cycle accumulation and significantly enhanced cellular resistance to radiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may represent a potential therapeutic target for enhancing tumor sensitivity to radiation
    ANIMAL & CELL MODELS