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FLASH GENE
Symbol RBM22 contributors: mct - updated : 17-09-2019
HGNC name RNA binding motif protein 22
HGNC id 25503
Location 5q33.1      Physical location : 150.070.352 - 150.080.669
Synonym name
  • functional spliceosome-associated protein 47
  • zinc finger CCCH domain-containing protein 16
  • Synonym symbol(s) ZC3H16, Cwc2, fSAP47, FLJ10290
    DNA
    TYPE functioning gene
    STRUCTURE 10.30 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2299 - 420 - 2012 22246180
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Endocrineneuroendocrinepituitary  moderately
    Lymphoid/Immunespleen   predominantly
     thymus   highly
    Nervousbrain   moderately
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion moderately in blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal zinc-binding domain
  • a C-terminal RRM domain
  • conjugated RiboP
    HOMOLOGY
    interspecies ortholog to murine Rbm22 (100pc)
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • RBM22 promote an active conformation of the spliceosome catalytic centre
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule metal binding, nucleotide,
    Zn2+
    protein
  • RBM22 which can shuttle between the cytoplasm and the nucleus may play a role in nuclear translocation of PDCD6
  • functional interaction between the Ca(2+)-signaling protein PDCD6 and the RNA-binding protein RBM22
  • PDCD6 is interacting with RBM22, a highly conserved spliceosomal nuclear protein
  • RBM22 enhances the cytoplasmic translocation of SLU7 under stress, especially a stress induced by thapsigargin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS