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FLASH GENE
Symbol RBM15 contributors: SGE/npt - updated : 04-09-2020
HGNC name RNA binding motif protein 15
HGNC id 14959
Location 1p13.3      Physical location : 110.881.944 - 110.889.303
Synonym name
  • one twenty two protein
  • Split ends
  • Synonym symbol(s) OTT, SPEN, FLJ12479, OTT1, FLJ21943, MGC119584
    DNA
    TYPE functioning gene
    STRUCTURE 7.36 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    text structure intronless
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 3450 106.4 977 - 2015 26575292
  • playing a role in chromatin organization through the binding of AT-rich DNA sequences, reconized by the SAF (scarffold attachement factor box)
  • candidate oncoprotein
  • 2 - 3262 - 969 - 2015 26575292
    also called short form
    - - 6800 205.8 1905 - 2015 26575292
    also called chimeric protein OTT-MKL1
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three RNA recognition motifs and a Spen paralog and ortholog
  • C terminal domain SPOC
  • HOMOLOGY
    interspecies homolog to Drosophila split-end (Spen)
    Homologene
    FAMILY
  • RRM Spen family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nuclear envelope
    basic FUNCTION
  • having nucleic acid binding activity
  • acting by promoting mRNA export from the nucleus (Lindtner 2006)
  • required for efficient mRNA export (Zolotukhin 2009)
  • RBM15 is required to preserve hematopoietic stem cell (HSC) quiescence during stress but not steady-state hematopoiesis
  • requirement for RBM15 in stress hematopoiesis, suggesting that RBM15-dependent processes may converge with those affected by aging
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the NXF1 pathway (Lindtner 2006)
  • INTERACTION
    DNA
    RNA
  • recognizes RNA transport element (RTE) directly and specifically in vitro and stimulates export and expression of RTE-containing reporter mRNAs (Lindtner 2006)
  • small molecule
    protein
  • interaction with the Epstein-Barr virus mRNA export factor EB2 (Hiriart 2005)
  • RBM15-MKL1 fusion gene is a constitutive activator of SRF and target gene expression, and deregulated activator of serum response factor-dependent gene expression contributes to the malignancy) (Descot 2008)
  • interaction of RBM15B and RBM15 with NXF1 via their C-terminal regions (Uranishi 2009)
  • binding specifically to DDX19B and facilitating its direct contact with mRNA (Zolotukhin 2009)
  • RBM15-MRTFA interacts with the SETD1B histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation
  • RBM15, a subunit of the m6A methyltransferase complex, interacts with SMARCC1 mRNA and mediates SMARCC1 mRNA degradation through the mRNA methylation machinery
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    in various neoplasias
    tumoral fusion      
    RBM15-MRTFA fusion protein is the result of the recurrent translocation t(1;22) in acute megakaryocytic leukemia in infants (Descot 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • ZFHX3, MACF1, RBM15, and SETD2 are Orofacial cleft candidate risk genes
  • Marker
    Therapy target
    ANIMAL & CELL MODELS