basic FUNCTION
| inhibiting TGFB1 activity by displacing E2F1 when overexpressed |
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positive control of cell proliferation and differentiation |
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playing a role in oncogenesis |
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modulates sex-specific radiation responses (Cassie 2006) |
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role for RBBP9 in tumor cell proliferation (Shields 2010) |
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acting as an inhibitor of basal or autocrine TGF-beta signaling and having a role in the suppression of Smad2/3 phosphorylation (Shields 2010 |
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tumor-associated serine hydrolase that displays elevated activity during neoplasia (Shields 2010) |
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RBBP4, RBBP9 are required for maintenance of multiple human pluripotent stem (PS) cell types |