Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RBBP9 contributors: mct/npt - updated : 28-11-2018
HGNC name retinoblastoma binding protein 9
HGNC id 9892
Location 20p11.23      Physical location : 18.467.189 - 18.477.887
Synonym name
  • B5T overexpressed gene protein
  • retinoblastoma-binding protein 10
  • protein BOG
  • Synonym symbol(s) BOG, RBBP10, MGC9236, RBBP10
    EC.number 3.-.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 10.70 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PCSK2 20p11.2 proprotein convertase subtilisin/kexin type 2 BFSP1 20p11.23 beaded filament structural protein 1, filensin RPS27AP2 20p11.2 ribosomal protein S27a pseudogene 2 DSTN 20p11.23 destrin (actin depolymerizing factor) RRBP1 20p12-p11.2 ribosome binding protein 1 homolog 180kDa (dog) C20orf179 20 chromosome 20 open reading frame 179 SNX5 20pter-q11.23 sorting nexin 5 C20orf72 20p11.23 chromosome 20 open reading frame 72 PTMAP3 20p11.23 prothymosin, alpha pseudogene 3 (gene sequence 34) ZNF339 20pter-q11.23 zinc finger protein 339 RPL15P1 20p11.23 ribosomal protein L15 pseudogene 1 CSRP2BP 20p11.23 CSRP2 binding protein ZNF133 20p11.23-p11.22 zinc finger protein 133 (clone pHZ-13) C20orf12 20p11.23 chromosome 20 open reading frame 12 POLR3F 20p11.23 polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa RBBP9 20p11.2 retinoblastoma binding protein 9 RPS19P1 20p11.23 ribosomal protein S19 pseudogene 1 SEC23B 20pter-p12.3 Sec23 homolog B (S. cerevisiae) LOC388789 20 hypothetical gene supported by AF147354 HARS2 20p11.23 histidyl-tRNA synthetase 2 HSPC072 20p11.23 HSPC072 protein C20orf78 20p11.23 chromosome 20 open reading frame 78 C20orf79 20 chromosome 20 open reading frame 79 SLC24A3 20p13 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 LOC388790 20 LOC388790 RPL12L3 20p11.22 ribosomal protein L12-like 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 3871 21 186 - Chen (2002)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Rb-binding motif LXCXE
  • HOMOLOGY
    interspecies homolog to murine Bog Rbbp9
    homolog to rattus Rbbp9
    Homologene
    FAMILY
  • RBBP9 family
  • CATEGORY enzyme , regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • inhibiting TGFB1 activity by displacing E2F1 when overexpressed
  • positive control of cell proliferation and differentiation
  • playing a role in oncogenesis
  • modulates sex-specific radiation responses (Cassie 2006)
  • role for RBBP9 in tumor cell proliferation (Shields 2010)
  • acting as an inhibitor of basal or autocrine TGF-beta signaling and having a role in the suppression of Smad2/3 phosphorylation (Shields 2010
  • tumor-associated serine hydrolase that displays elevated activity during neoplasia (Shields 2010)
  • RBBP4, RBBP9 are required for maintenance of multiple human pluripotent stem (PS) cell types
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text cell cycle control
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • retinoblastoma binding
  • inhibits neoplastic TGF-beta signaling through suppression of Smad2/3 phosphorylation, which in turn promotes proliferation as well as tumor cell cohesiveness, implicating this tumor-associated serine hydrolase as a key enzyme in malignant transformation (Shields 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic carcinoma cells (Shields 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CYFIP2 and RBBP9 are two novel ALS (amyotrophic lateral sclerosis) potential biomarkers in non-neural tissues from ALS patients that may have direct diagnostic and therapeutic implications to the disease
  • Therapy target
    ANIMAL & CELL MODELS