basic FUNCTION
| potential modulator of BRCA1 in transcriptional regulation, DNA repair and cell cycle checkpoint control |
|
controls double strand break (DSB) resection, an event that occurs effectively only in S/G(2) and that promotes homologous recombination but not non-homologous end joining |
|
modulates responses to DNA damage in a cell cycle-dependent manner |
|
cofactor for the transcriptional repressor CTBP1 and CTBP2 |
|
also implicated in DNA damage checkpoint control through its interaction with the breast cancer susceptibility gene product BRCA1 |
|
recruited to S-phase DNA replication foci through a novel motif functioning as replication foci targeting sequence (RFTS) |
|
is a key substrate by which SIRT6 facilitates DSB processing and homologous recombination |
|
new functions of RBBP8 and EXO1 in DNA end resection, preventing genomic instability |
|
essential role in chromosomal translocation formation through an alternative end-joining pathway |
|
plays an essential role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair |
|
RBBP8-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation |
|
is a conserved DNA repair protein that facilitates DNA end resection in the double-strand break (DSB) repair pathway |
|
plays a critical role during initiation of DNA interstrand crosslinks (ICLs) processing in replicating human cells that is distinct from its role in DSB repair |
|
involved in cell cycle progression, DNA repair and transcriptional regulation |
|
|