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FLASH GENE
Symbol RBBP6 contributors: - updated : 20-05-2006
HGNC name retinoblastoma binding protein 6
HGNC id 9889
Location 16p12-p11.2      Physical location : 24.550.907 - 24.584.181
Synonym name
  • RB-binding Q-protein 1
  • proliferation potential-related protein
  • Synonym symbol(s) MY038, P2P-R, RBQ1
    DNA
    TYPE functioning gene
    STRUCTURE 14.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1203 16p12.3 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 SCNN1G 16p12.2-p12.1 sodium channel, nonvoltage-gated 1, gamma SCNN1B 16p12.2-p12.1 sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) COG7 16p11.2 component of oligomeric golgi complex 7 GGA2 16p12 golgi associated, gamma adaptin ear containing, ARF binding protein 2 UBPH 16p12 similar to ubiquitin binding protein NDUFAB1 16p12.3-p12.1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa FLJ21816 16p12.3 hypothetical protein FLJ21816 MGC3248 16p12.3 dynactin 4 PLK LOC388226 16 similar to protein kinase/ribonuclease IRE1 beta ERN2 16p12.2 ER to nucleus signalling 2 LOC63928 16p12.3 hepatocellular carcinoma antigen gene 520 PRKCB1 16p12.1 protein kinase C, beta 1 CACNG3 16p13-p12.1 calcium channel, voltage-dependent, gamma subunit 3 RNU7P3 16p12.3 RNA, U7 small nuclear pseudogene 3 RBBP6 16p12-p11.2 retinoblastoma binding protein 6 TNRC6 16p12.1-p11.2 trinucleotide repeat containing 6 KST1 16p12.2-p11.2 trinucleotide repeat containing 6 RICH1 16p12-p11.2 Homo sapiens homolog of rat nadrin (RICH1), mRNA. LOC390685 16 hypothetical gene supported by BC041358 LOC342355 16p12.2 similar to hypothetical protein LOC388227 16 LOC388227 LCMT1 16p12.3-p12.1 leucine carboxyl methyltransferase 1 AQP8 16p12 aquaporin 8 LOC342357 16p12.2 similar to hypothetical protein FLJ35867 HCP39 16p12.2 cytochrome c, somatic pseudogene HS3ST4 16p11.2 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 EPF8 16p12.2 EPF8 pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 6853 - 1792 - Scott
    - - 6751 - 1758 - Scott
    - - 1780 - 118 - Scott
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemplacenta  highly
     male systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a lot of short repetitive sequences, in its central region
  • a ring-type zinc finger
  • HOMOLOGY
    interspecies ortholog to murine Rbbp6
    homolog to rattus Rn.61207
    homolog to zebrafish Dr.18039
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having potential functional roles in the control of gene expression and mitosis
  • may modulate translation by influencing ribosomal protein gene expression
  • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    text regulation of cell cycle
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • binding to underphosphorylated RB1, and TP53
  • cell & other
    REGULATION
    Other translationally regulated by PUM2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS