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FLASH GENE
Symbol RBBP4 contributors: mct - updated : 22-12-2015
HGNC name retinoblastoma binding protein 4
HGNC id 9887
Location 1p35.1      Physical location : 33.116.748 - 33.151.810
Synonym name
  • chromatin assembly factor /CAF-1 p48 subunit
  • retinoblastoma-binding protein p48
  • nucleosome-remodeling factor subunit RBAP48
  • MSI1 protein homolog
  • CAF-1 subunit C
    • Synonym symbol(s) RBAP48, Mis16, NURF55
    DNA
    TYPE functioning gene
    STRUCTURE 35.06 kb     12 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 7943 47.52 425 - 2008 19015307
    12 - 7940 47.45 424 - 2008 19015307
    12 - 7843 43.35 390 - 2008 19015307
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineadrenal gland   highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • WD40 repeats domain
    • HOMOLOGY
    interspecies homolog to yeast Mis16
    intraspecies homolog to RBBP7
    Homologene
    FAMILY
  • WD repeat RBAP46/RBAP48/MSI1 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • required with RBBP7 for the recruitement of CENPA to the kinetochores
  • its overexpression induces TP53-mediated apoptosis in the exocrine glands caused by estrogen deficiency
  • associated with chromatin remodeling, histone deacetylation, and transcription repression, as proteins associated with the DNA-bound ESR1
  • playing a role in regulating gene expression
  • limits expression of estrogen-responsive genes
  • inducing tissue-specific apoptosis in the exocrine glands depending on the level of estrogen deficiency
  • critical mediator controlling the transforming activity of HPV16 in cervical cancer
  • RBBP4, RBBP9 are required for maintenance of multiple human pluripotent stem (PS) cell types
  • role in DNA replication-coupled histone deposition
  • also has a role in higher order chromatin organization and heterochromatin-mediated gene expression
  • potential novel epigenetic function in promoting NOTCH pathway activity that regulates normal development
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text negative control of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
  • of the chromatin remodeling complexes (NURF complex)
  • RBBP4·ZFPM1 structure provides insight into the molecular determinants of ZFPM1-dependent association with the NuRD complex and into the links between transcription regulation and nucleosome remodeling
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with ESR1
  • interacts with EED, SUZ12 and EZH2 to form the polycomb repressive complex 2 (PRC2), which functions to initiate epigenetic silencing of genes involved in cell fate decisions
  • RBBP4-MTA1 interaction is essential for the integration of RBBP7/RBBP4 into the NuRD complex
  • histone chaperone protein RBBP4, bind to the C-terminal tail of MTA1, and MTA1 recruits a second copy of RBBP4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • up-regulation of RbAp48 in the dentate gyrus of aged wild-type mice ameliorated age-related hippocampus-based memory loss and age-related abnormalities in histone acetylation