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FLASH GENE
Symbol RBAK contributors: SGE/npt - updated : 13-04-2010
HGNC name RB-associated KRAB zinc finger
HGNC id 17680
Location 7p22.1      Physical location : 5.085.552 - 5.109.119
Synonym name
  • RB-associated KRAB repressor
  • hRBaK
  • zinc finger protein 769
  • Synonym symbol(s) ZNF769
    DNA
    TYPE functioning gene
    STRUCTURE 23.57 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC392858 7 similar to hypothetical protein FLJ10307 LOC392936 7 similar to ribosomal protein L31 FLJ10099 7q11.22 hypothetical protein FLJ10099 RBAK 7p22.2 hypothetical protein FLJ10099 LOC221937 7p22.2 forkhead box K1 LOC392622 7 hypothetical gene supported by BC031661 SBDS 7q11.21 Shwachman-Bodian-Diamond syndrome FLJ10900 7q11.22 hypothetical protein FLJ10900 FLJ20485 7q22.2 hypothetical protein FLJ20485 LOC392859 7 similar to olfactory receptor MOR267-3 LOC285924 7p22.2 hypothetical protein LOC285924 KIAA0415 7p22.2 KIAA0415 gene product FLJ11785 7q22.2 Rad50-interacting protein 1 FLJ10324 7p22 hypothetical protein FLJ10324 DKFZP434J154 7p22.2 DKFZP434J154 protein LOC392773 7 hypothetical gene supported by M24070; NM_004559 PAPOLB 7p22.2 poly(A) polymerase beta (testis specific) LOC392774 7 similar to KIAA1218 protein SLC29A4 7p22.2 solute carrier family 29 (nucleoside transporters), member 4 PAQR10 7p22.2 progestin and adipoQ receptor family member X KIAA1856 7p22.2 KIAA1856 protein LOC391996 7 similar to hypothetical protein FLJ10307 LOC392712 7 similar to Williams-Beuren syndrome critical region protein 19 LOC392713 7 similar to PMS4 homolog mismatch repair protein - human FLJ13195 7p11.2-q11.2 hypothetical protein FLJ13195 similar to stromal antigen 3 MGC33190 7q22.2 hypothetical protein MGC33190 LOC392623 7 LOC392623 FLJ11467 7p22.2 hypothetical protein FLJ11467 RBAK 7p22.2 hypothetical protein FLJ11467 LOC389458 7 hypothetical gene supported by BC031661 LOC391997 7 similar to olfactory receptor MOR267-3 LOC285924 7p22.2 hypothetical protein LOC285924 ACTB 7p22 actin, beta LOC392860 7 similar to Calgizzarin (S100C protein) (MLN 70) LOC392945 7 similar to 60S ribosomal protein L10 (QM protein homolog) DKFZP434J154 7p22.2 DKFZP434J154 protein FSCN1 7p22 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) GNAI1 7q21.3-q22.1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 TRIAD3 7p22.2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 FLJ23834 7q22.2 hypothetical protein FLJ23834 SLC29A4 7p22.2 solute carrier family 29 (nucleoside transporters), member 4 KIAA1856 7p22.2 KIAA1856 protein SYPL 7q22.1-q31.1 synaptophysin-like protein LOC389459 7 LOC389459 FLJ11467 7p22.2 hypothetical protein FLJ11467 LOC392624 7 similar to hypothetical protein LOC285924
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 6551 - 714 - Skapek (2000)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemplacenta   
    Respiratorylung    
    Skeleton     
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 16 C2H2-type zinc fingers
  • one KRAB domain
  • HOMOLOGY
    interspecies homolog to murine Rbak (79.7pc)
    homolog to rattus Rbak (79.0pc)
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may contribute to RB-dependent suppression of E2F-mediated transcriptional activation and RB-mediated cell cycle arrest
  • may promote AR-dependent transcription (Hofman 2003)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text transcriptional repressor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ binding
  • protein
  • interacting with RB1
  • interacting with AR (Hofman 2003)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP RBaK (-)2031T/2030G/834C/821T alleles may have functional roles contributing to the FH-II phenotype (Jeske 2008)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS