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FLASH GENE
Symbol RAVER2 contributors: mct - updated : 04-05-2017
HGNC name ribonucleoprotein, PTB-binding 2
HGNC id 25577
Location 1p31.3      Physical location : 65.210.777 - 65.298.912
Synonym name
  • novel protein containing an RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
  • raver2
  • Synonym symbol(s) FLJ10770, KIAA1579
    DNA
    TYPE functioning gene
    STRUCTURE 88.25 kb     12 Exon(s)
    regulatory sequence Promoter
    text structure
  • putative promoter region in a 1000bp region upstream of the transcription starting site of the gene
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4376 - 678 - 2012 22146317
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Hearing/Equilibriumearinnercochlea highly
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two putative nuclear localization signals
  • a potential nuclear export sequence
  • two putative PTB binding sequences in the C-terminal half of the protein
  • HOMOLOGY
    Homologene
    FAMILY hnRNP family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may participate in polypyrimidine tract binding protein -mediated nuclear functions
  • exerts a distinct spatio-temporal expression pattern during embryogenesis
  • RAVER2, like RAVER1, may function as a modulator of PTB activity
  • is a putative modulator of the activity of the polypyrimidine-tract binding protein (PTB), one of the most intensively studied splicing repressors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with polypyrimidine tract binding protein (PTB)
  • interacts with PTBP1 and RAVER1
  • may bind single stranded nucleic acids
  • deregulation of LMNB1 expression induces modified splicing of several genes, likely driven by RAVER2 overexpression, and suggest that an alteration of mRNA processing could be a pathogenic mechanism in ADLD
  • cell & other
    REGULATION
    Other regulation of RAVER2 expression involves TATA-less transcriptional activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ulcerative colitis
    Variant & Polymorphism SNP
  • rs2780814 is significantly associated with ulcerative colitis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS