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FLASH GENE
Symbol RAVER1 contributors: mct - updated : 27-08-2014
HGNC name ribonucleoprotein, PTB-binding 1
HGNC id 30296
Location 19p13.2      Physical location : 10.426.890 - 10.444.314
Genatlas name RAVER1
Synonym symbol(s) KIAA1978
DNA
TYPE like-sequence
STRUCTURE 17.43 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure
  • several consensus Sp1 putative binding sequences can be predicted within 1 kb from the transcription start site (TSS)
  • promoter region shares common features of ubiquitously expressed gene with the interacting splicing regulator PTB
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3606 - 756 - 2011 21633983
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
    Lymphoid/Immunelymph node   moderately
     spleen   moderately
     thymus   highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region of RAVER1 has three RNA recognition motif (RRM1, RRM2, and RRM3) domains, and RRM1 interacts with the vinculin tail (Vt) domain and vinculin mRNA
  • two putative nuclear localization signals
  • a potential nuclear export sequence
  • mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Raver1 (87 p100)
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • migrating from the nucleus to the costamere during muscle differentiation
  • basic FUNCTION
  • involved in nuclear mRNA splicing, via spliceosome
  • may coordinate RNA processing and targeting
  • acting as a polypyrimidine tract-binding protein (PTB/hnRNPI) co-repressor in regulating alternative splicing events
  • processing regulator that cooperate with PTB protein in modulating inclusion/exclusion of specific exons
  • may play an important role for the regulation of neuronal synaptic plasticity, possibly by controlling especially the late LTP via posttranscriptional mechanisms
  • RAVER2, like RAVER1, may function as a modulator of PTB activity
  • specifically regulates IFIH1 activity, revealing a mechanism of differential regulation of IFIH1- and DDX58-mediated innate antiviral response
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • microfilament-associated proteins vinculin
  • metavinculin
  • alpha-actinin
  • interactions with VCl and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions
  • RAVER1-PTBP1 interaction is a general mode of binding that applies to RAVER1 complexes with PTB paralogues
  • regulates the assembly of focal adhesions transcriptionally by binding to VCL (metavinculin can bind to RAVER1 in its inactive state)
  • is a specific IFIH1-interacting protein (RAVER1 was associated with IFIH1 upon viral infection)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS