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FLASH GENE
Symbol RASSF7 contributors: mct/ - updated : 13-03-2010
HGNC name Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
HGNC id 1166
Location 11p15.5      Physical location : 560.970 - 564.024
Synonym name
  • Ras association (RalGDS/AF-6) domain family 7
  • HRAS1-related cluster-1
  • chromosome 11 open reading frame 13
  • ras association domain-containing protein 7
  • Synonym symbol(s) MGC126069, MGC126070, D11S978E, HRC1, HRAS1, C11orf13
    DNA
    TYPE functioning gene
    STRUCTURE 3.06 kb     6 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map see MUCDHL
    regionally located located 19kb upstream of HRAS
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1746 - 337 - 1992 1339391
    5 - 1471 - 320 - 1992 1339391
    6 - 1554 - 373 - 1992 1339391
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     stomach    
    Reproductivefemale systemuteruscervix  
    Skin/Tegumentskin    
    cell lineage
    cell lines bladder carcinoma
    fluid/secretion
    at STAGE
    physiological period embryo
    Text in several embryonic tissues including the skin, eyes, and neural tube
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal Ras-Association domain
  • regions rich in glutamine and proline
  • a region similar to the helix-loop-helix (HLH) motif adjacent to a C terminal leucine zipper dimerization motif with four heptad repeats
  • ras-associating domain
  • HOMOLOGY
    interspecies ortholog to rattus LOC293623
    Homologene
    FAMILY
  • N-terminal RASSF family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • endogenous RASSF7 protein localizes to the centrosome
  • not recruited to the centrosome during mitosis, but localizes there in dividing and non-dividing cells
  • basic FUNCTION
  • methylated-DNA-[protein]-cysteine S-methyltransferase activity
  • may function as tumour suppressors by regulating the cell cycle and apoptosis
  • having a role in spindle formation
  • centrosome-associated protein required to form a spindle and complete mitosis in the neural tube *
  • required for mitosis, a complex process involving microtubule nucleation from the spindle pole and the stable attachment of microtubules to the kinetochore
  • potential Ras effector implicated in key biological processes, including cell death, proliferation, microtubule stability, promoter methylation, vesicle trafficking and response to hypoxia
  • important regulator of microtubule dynamics
  • function crucially important for mitosis because it regulates microtubule growth from the centrosome
  • essential for anchorage-independent growth of tumoral cells
  • acts in concert with N-Ras to constitute a stress-sensitive temporary mechanism of apoptotic regulation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • integral centrosomal component whose localization is microtubule-independent
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with AURKB (primary role of RASSF7 is in regulating microtubule growth and mis-regulation of this process is responsible for the spindle defects and the loss of Aurora B activation)
  • interacts with N-Ras and mitogen-activated protein kinase kinase 7 (MAP2K7) to negatively regulate c-Jun N-terminal kinase (JNK) signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    resulted in a failure in chromosomal congression, demonstrated by an increase in the number of mitotic cells which had failed to align their chromosomes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS