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FLASH GENE
Symbol RASSF6 contributors: mct/npt - updated : 06-06-2014
HGNC name Ras association (RalGDS/AF-6) domain family member 6
HGNC id 20796
Location 4q13.3      Physical location : 74.438.861 - 74.486.340
Synonym name
  • Ras association (RalGDS/AF-6) domain family 6
  • putative RAS binding protein
  • Synonym symbol(s) DKFZp686K23225
    DNA
    TYPE functioning gene
    STRUCTURE 49.08 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ38991 4q21.1 hypothetical protein FLJ38991 ANKRD17 4q13.3 ankyrin repeat domain 17 HMGA1L2 4q21.1 high mobility group AT-hook 1-like 2 ALB 4q11-q13 albumin AFP 4q11-q13 alpha-fetoprotein AFM 4q11-q13 afamin RASSF6 4q21.21 Ras association (RalGDS/AF-6) domain family 6 IL8 4q13-q21 interleukin 8 CXCL6 4q21 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) PF4V1 4q13-q21 platelet factor 4 variant 1 CXCL1 4q21 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) CXCL1P 4q21.21 chemokine (C-X-C motif) ligand 1 pseudogene PF4 4q13-q21 platelet factor 4 (chemokine (C-X-C motif) ligand 4) PPBP 4q12-q13 pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) CXCL5 4q13-q21 chemokine (C-X-C motif) ligand 5 CXCL3 4q21 chemokine (C-X-C motif) ligand 3 SPBPBP 4q21.21 DNA-binding protein amplifying expression of surfactant protein B CXCL2 4q21 chemokine (C-X-C motif) ligand 2 LOC255324 4q21.21 similar to ALGV3072 EREG 4q25-q26 epiregulin AREG 4q13-q21 amphiregulin (schwannoma-derived growth factor)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 4268 - 337 - 2007 17367779
    isoform a
    11 - 4323 - 369 - 2007 17367779
    isoform b
    10 - 5818 - 325 - 2007 17367779
    10 - 5938 - 303 - 2007 17367779
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemprostate   
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Sav/RASSF/Hippo (SARAH) domain (Ikeda 2007)
  • a C-terminal Ras-association (RA) domain that binds activated Ras (Allen 2007)
  • HOMOLOGY
    Homologene
    FAMILY RASSF family proteins
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may play a role in dictating the degree of inflammatory response to the respiratory syncytial virus (Allen 2007)
  • demonstrates the properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members (Allen 2007)
  • implicated in apoptosis in HeLa cells and it triggers both caspase-dependent and caspase-independent pathways (Ikeda 2007)
  • may function as tumour suppressors by regulating the cell cycle and apoptosis (van der Weyden 2007)
  • caused apoptosis when released from activated STK3 in a manner dependent on WW45, the mammalian Salvador homolog (Ikeda 2009)
  • antagonizes Hippo signaling and mediates apoptosis through a pathway that is parallel to the canonical Hippo pathway (Ikeda 2009)
  • stabilizes TP53, regulates apoptosis and the cell cycle, and functions as a tumor suppressor
  • involved in TP53-mediated G1/S arrest
  • RASSF6 may play a tumor suppressor role in the progression of clear cell renal cell carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds RAS
  • bound to STK3 (RASSF6 inhibited STK3 activity to antagonize Hippo signaling) (Ikeda 2009)
  • binds MDM2 and facilitates its ubiquitination
  • RASSF6 triggers CDKN1A accumulation to induce G 1 cell cycle arrest and promote apoptosis upon exposure to pro-apoptotic agents
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS