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FLASH GENE
Symbol RASSF3 contributors: mct/npt - updated : 15-03-2010
HGNC name Ras association (RalGDS/AF-6) domain family 3
HGNC id 14271
Location 12q14.2      Physical location : 65.004.292 - 65.089.190
Synonym symbol(s) MGC119194, MGC119195, MGC119197, RASSF5
DNA
TYPE functioning gene
STRUCTURE 84.90 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC144583 12q14.1 hypothetical gene supported by AK025388 USP15 12q14 ubiquitin specific protease 15 KIAA1040 12q14.1 KIAA1040 protein FLJ25590 12q14.1 hypothetical protein FLJ25590 ARHCL1 12q14.1 ras homolog gene family, member C like 1 LOC390337 12 similar to RIKEN cDNA A430075L18 gene LOC144581 12q14.1 similar to ribosomal protein L14; 60S ribosomal protein L14 LOC121498 12q14.1 similar to lactate dehydrogenase A -like AVPR1A 12q14 arginine vasopressin receptor 1A FLJ32949 12q14.1 hypothetical protein FLJ32949 LOC390338 12 similar to T-box transcription factor TBX20 TMEM5 12q14.1 transmembrane protein 5 LOC341315 12q14.1 similar to Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1) SRGAP1 12q13.13 SLIT-ROBO Rho GTPase activating protein 1 FLJ32549 12q14.1 hypothetical protein FLJ32549 LOC115749 12q14.1 hypothetical protein LOC115749 LOC390339 12 similar to 40S ribosomal protein S11 XPOT 12q14 exportin, tRNA (nuclear export receptor for tRNAs) TBK1 13q14.2-q14.3 TANK-binding kinase 1 RASSF3 12q14.1 Ras association (RalGDS/AF-6) domain family 3 GNS 12q14 glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) KIAA0984 12q13.13 glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) WIF1 12q13.13 WNT inhibitory factor 1 MAN1 12q14 WNT inhibitory factor 1 LOC253827 12q14.1 hypothetical protein LOC253827 LOC387865 12 LOC387865 LOC204010 12q14.2 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) HMGA2 12q14-q15 high mobility group AT-hook 2 LOC341321 12q14.2 similar to 60S ribosomal protein L21 MGC14817 12q14.2 hypothetical protein MGC14817 CGI-119 12q14.1-q15 CGI-119 protein IRAK3 12q13.13 interleukin-1 receptor-associated kinase 3 RBMS1P 12q14.2 RNA binding motif, single stranded interacting protein 1, pseudogene LOC387866 12 LOC387866 LOC390340 12 similar to IAP-associated factor VIAF1; phosducin-like 2 HELB 12q14.2 helicase (DNA) B GRIP1 12q14.1-q14.2 glutamate receptor interacting protein 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1337 - 238 - Tommasi (2002)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly conserved Ras association (RalGDS/AF-6) (RA) domain at the C-terminus
  • HOMOLOGY
    intraspecies homolog to RASSF1
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • may be involved in neuropeptide signaling pathway
  • may function as tumour suppressors by regulating the cell cycle and apoptosis (van der Weyden 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    may influence mammary tumor incidence in MMTV/neu transgenic mice (Jacquemart 2009)