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FLASH GENE
Symbol RASSF2 contributors: mct - updated : 21-04-2010
HGNC name Ras association (RalGDS/AF-6) domain family member 2
HGNC id 9883
Location 20p13      Physical location : 4.760.669 - 4.804.291
Synonym name
  • rasfadin
  • Ras association domain family 2
  • ras association domain-containing protein 2
  • Synonym symbol(s) KIAA0168, GIG22, DKFZp781O1747
    DNA
    TYPE functioning gene
    STRUCTURE 43.62 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    C20orf28 20pter-q11.23 chromosome 20 open reading frame 28 CENPB 20p13 centromere protein B, 80kDa CDC25B 20p13 cell division cycle 25B C20orf29 20p13 chromosome 20 open reading frame 29 KIAA1271 20p13 KIAA1271 protein PANK2 20p13 pantothenate kinase 2 (Hallervorden-Spatz syndrome) RNF24 20p13-p12.1 ring finger protein 24 LOC388783 20 similar to hypothetical protein RPL21P2 20p13 ribosomal protein L21 pseudogene 2 MGC34919 20p13 hypothetical protein MGC34919 SMOX 20p13 spermine oxidase ADRA1D 20p13 adrenergic, alpha-1D-, receptor RPL7AL2 20p13 ribosomal protein L7a like 2 RPS4L2 20p13 ribosomal protein S4-like 2 PRNP 20p12.3 prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) PRND 20pter-p12 prion protein 2 (dublet) LOC149830 20p13 M8 protein RASSF2 20pter-p12.1 Ras association (RalGDS/AF-6) domain family 2 SLC23A2 5q31.2-q31.3 solute carrier family 23 (nucleobase transporters), member 2 C20orf30 20p13 chromosome 20 open reading frame 30 PCNA 20p12.3 proliferating cell nuclear antigen CDS2 20p13 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 LOC388784 20 similar to dJ680N4.2 (ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5)) GPR73L1 20p13 G protein-coupled receptor 73-like 1 LOC388785 20 hypothetical gene supported by AK090863 MGC35023 20p13 hypothetical protein MGC35023 LOC388786 20 LOC388786 LOC388787 20 LOC388787 RPS18P1 20p13 ribosomal protein S18 pseudogene 1 KIAA1434 20p13 hypothetical protein KIAA1434 EIF4EL2 20p13 eukaryotic translation initiation factor 4E-like 2
    regionally located located near the prion gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 splicing 5426 37.8 326 - 2010 19962960
    11 splicing 5307 37.8 326 - 2010 19962960
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    Nervousbrain   highly
     nerve   highly
     spinal cord    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RAS (Ral GDS/AF-6) association domain (RA)
  • a SARAH domain
  • a C-terminal Ras-association (RA) domain and AAs between 240 to 260 harbor a functional nuclear export signal (NES), which is necessary and sufficient for efficient export of RASSF2 from the nucleus
  • HOMOLOGY
    interspecies homolog to Drosophila CG4656
    Homologene
    FAMILY
  • RASSF1 family of Ras effectors/tumor suppressors
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • cytoplasmic in presence of STK3
  • primarily a nuclear protein, and shuttling of PAWR from the cytoplasm to the nucleus is essential for its function
  • basic FUNCTION
  • acting as a KRAS-specific effector protein
  • may promote apoptosis and cell cycle arrest
  • tumor suppressor gene that regulates Ras signaling and plays a pivotal role in the early stages of colorectal tumorigenesis
  • may function as tumour suppressors by regulating the cell cycle and apoptosis
  • promotes apoptosis and cell cycle arrest and exhibits a specificity for interacting with K-Ras
  • is maintained in a phosphorylated state and protects STK3 from degradation and turnover
  • involved in the suppression of cell growth and is frequently down-regulated in various tumor tissues by promoter hypermethylation
  • regulates cell growth in a nuclear localization dependent manner
  • also engages the JNK pathway and induces apoptosis in an MST1-independent manner
  • functions as a novel regulator of MST1 kinase, and controls MST1 activity under pro-apoptotic conditions
  • implicated as a tumor suppressor whose inactivation facilitates transformation by disconnecting apoptotic responses from Ras
  • modulates the nuclear translocation of PAWR in prostate tumor cells, providing a mechanism for its biological effects
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    neuropeptide signaling pathway
    a component
  • forming an active complex with STK3
  • forms a direct and endogenous complex with PAWR
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds directly to K-Ras in a GTP-dependent manner via the Ras effector domain
  • interacting with MST1 (acts in a complex manner that extends beyond simple protein–protein association to play an important role in MST1 regulation)
  • K-Ras effector that modulates PAWR action
  • may interact with other proapoptotic effectors/tumor suppressors to mediate cell death
  • cell & other
    REGULATION
    Other specifically phosphorylated by MAPK/ERK-2 (plays an important role in regulating the nucleo-cytoplasmic shuttling of RASSF2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by methylation in colorectal adenomas
    tumoral       loss of function
    inactivated by its promoter methylation and this by aberrant methylation correlates with lymph node metastasis in nasopharyngeal carcinoma
    tumoral       loss of function
    silenced by CpG island hypermethylation in gastric cancer
    tumoral     --low  
    by hypermethylation in breast and lung carcinoma
    tumoral     --low  
    by frequent RASSF2 promoter methylation in prostate carcinoma
    tumoral     --low  
    in gastric cancer, by aberrant methylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene novel methylation marker for multiple malignancies and it has the potential to be developed into a valuable marker for screening several cancers in parallel using promoter hypermethylation profiles
    Marker
    Therapy target
  • key target for epigenetic therapy in prostate cancer
  • ANIMAL & CELL MODELS