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FLASH GENE
Symbol RASL11B contributors: mct/npt - updated : 14-10-2009
HGNC name RAS-like, family 11, member B
HGNC id 23804
Location 4q12      Physical location : 53.728.494 - 53.732.995
Synonym symbol(s) MGC2827, MGC4499
DNA
TYPE functioning gene
STRUCTURE 4.51 kb     4 Exon(s)
regulatory sequence cytosine-phosphate-guanine/HTF
text structure proximal 5'-flanking region of the gene lacks a TATA box but is GC-rich and contains a CCAAT box and several Sp1 sites (Stolle 2007)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1979 - 248 - Stolle (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale system   predominantly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • small GTPase protein family
  • Ras subfamily
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION
    text no typical prenylation signal, indicating that it is probably not anchored to cellular membranes (Stolle 2007)
    basic FUNCTION
  • small GTPase belonging to a Ras subfamily of putative tumor suppressor genes (Pezeron 2008)
  • may play a role in TGF-beta1-mediated developmental processes and in pathophysiologies such as inflammation, cancer, and arteriosclerosis (Stolle 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS