Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RASGRP3 contributors: mct - updated : 22-08-2014
HGNC name RAS guanyl releasing protein 3 (calcium and DAG-regulated)
HGNC id 14545
Location 2p22.3      Physical location : 33.661.415 - 33.789.797
Synonym name guanine nucleotide exchange factor for Rap1
Synonym symbol(s) KIAA0846, GRP3
DNA
TYPE functioning gene
STRUCTURE 128.38 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ37965 CAPN13 2p22-p21 similar to ADP,ATP carrier protein, fibroblast isoform (ADP/ATP translocase 2) (Adenine nucleotide translocator 2) (ANT 2) GALNT14 2p23.2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) EHD3 2p21.1 EH-domain containing 3 LOC391361 2 similar to ribosomal protein L21 XDH 2p23-p22.2 xanthine dehydrogenase SRD5A2 2p23 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) LOC391362 2 similar to human alpha-catenin LOC339736 2p23.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) CGI-27 2p23.2 C21orf19-like protein LOC84661 2p23.2 dpy-30-like protein SPG4 2p22-p21 spastic paraplegia 4 (autosomal dominant; spastin) SLC30A6 2p22.3 solute carrier family 30 (zinc transporter), member 6 RH-II/GuBp1 2p22-p21 RH-II/GuB pseudogene 1 CARD12 2p22-p21 caspase recruitment domain family, member 12 MGC11061 2p23.2 hypothetical protein MGC11061 BIRC6 2p22-p21 baculoviral IAP repeat-containing 6 (apollon) FLJ20272 2p23.2-p23.1 hypothetical protein FLJ20272 LOC391363 2 similar to Latent transforming growth factor beta binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1 binding protein 1) (TGF-beta1-BP-1) LTBP1 2p22-p21 latent transforming growth factor beta binding protein 1 RASGRP3 2p25.1-p24.1 RAS guanyl releasing protein 3 (calcium and DAG-regulated) DKFZP564F0522 2p23.1 DKFZP564F0522 protein LOC391364 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC151325 2p23.1 similar to hypothetical protein BC013995 LOC344371 2p23.1 similar to ADP,ATP carrier protein, fibroblast isoform (ADP/ATP translocase 2) (Adenine nucleotide translocator 2) (ANT 2) MRPL50P1 2p22.3 similar to ADP,ATP carrier protein, fibroblast isoform (ADP/ATP translocase 2) (Adenine nucleotide translocator 2) (ANT 2) CRIM1 2p21 cysteine-rich motor neuron 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 4711 - 690 - -
18 - 4798 - 690 - -
17 - 4353 - 689 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver    
Nervousbrain   highly
Reproductivefemale systemplacenta   
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one N-terminal Ras-GEF domain
  • two EF-hand calcium binding motifs
  • one zinc-dependent diacylglycerol/phorbol ester binding domain (C1 domain)
  • HOMOLOGY
    interspecies homolog to murine LOC240168
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text redistributed to perinuclear regions in response to phorbol ester treatment
    basic FUNCTION
  • GTPase activator activity
  • guanyl-nucleotide exchange factor activity
  • signal transducer activity
  • serves as a PKC-independent pathway to link the tumor-promoting phorbol esters with activation of Ras GTPases
  • implicated in phorbol ester-induced, PKC-independent exocytosis
  • exchange factor for Ras-like small GTPases that is activated in response to the second messenger diacylglycerol
  • mediates the activation of the Ras signaling pathway that is present in many human cancers
  • contributes to developmental defects found in embryos that develop in a diabetic environment
  • activator for HRAS, RRAS and Ras-associated protein-1/2, has emerged as an important mediator of signaling downstream from receptor coupled phosphoinositide turnover in B and T cells
  • its role in melanoma highlights its importance, as a RAS activator, in the phosphoinositide signaling pathway in melanoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Ca2+ binding
  • DAG binding
  • protein
  • also activates RAP1A, which in some cases can antagonize the function of RAS (RAP1A can antagonize the function of RAS, and DGKI regulates RASGRP3 with a predominant effect on RAP1A activity)
  • DYNLL1 is a RASGRP3-interacting protein (interaction required the C-terminal domain encompassing the last 127 AAs of RASGRP3)
  • RASGRP1, RASGRP3 may regulate progenitor entry into the thymus through a CCR9-dependent mechanism
  • cell & other
    REGULATION
    Other regulated by calcium and diacylglycerol binding
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductionpregnancy 
    may be a novel therapeutic target for the fetal complications of diabetes
    cancerreproductiveprostate
    may constitute a novel therapeutic target for human prostate cancer
    ANIMAL & CELL MODELS