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FLASH GENE

Symbol

RASGRP2

contributors: mlc/np - updated : 03-12-2007

HGNC name	RAS guanyl releasing protein 2 (calcium and DAG-regulated)
HGNC id	9879

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q13      Physical location : 64.494.383 - 64.512.928
Synonym name	calcium and diacyl glycerol regulated guamine nucleotide exchange factor1
	CDC25-like gene
	guanine exchange factor MCG7
	ecotropic virus integration site E.V.I.17
	calcium and diacylglycerol-regulated guanine nucleotide exchange factor I
	RAS guanyl releasing protein 2
Synonym symbol(s)	CDC25L, CALDAG, EVI17, CALDAG-GEFI

DNA

TYPE	functioning gene
STRUCTURE	18.00 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 2 - - 2310 - 609 - Katagiri (2004) variant 3 - - 2244 - 609 - Katagiri (2004) variant 4 - - 2284 - 609 - Katagiri (2004)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Lymphoid/Immune spleen       highly   thymus       highly Nervous brain         Reproductive male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol   bone marrow     highly Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	RAS-GEF domain
	phorbol esters
	diacylglycerol binding domain

HOMOLOGY

interspecies	homolog to C.elegans F25B3.3
	homolog to murine Rasgrp2

Homologene

FAMILY

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	likely involved in the control of cell cycle
	Rap1 exchange factor identified by megakaryocyte gene profiling as a candidate integrin regulator, enhanced agonist-induced activation of Rap1b and fibrinogen binding to alphaIIbbeta3

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS