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FLASH GENE
Symbol RASGRF2 contributors: mct - updated : 04/12/2008
HGNC name Ras protein-specific guanine nucleotide-releasing factor 2
HGNC id 9876
Location 5q14.1      Physical location : 80.256.557 - 80.521.953
Synonym name guanine nucleotide-releasing factor 2
Synonym symbol(s) RGRF2, GRF2, RAS-GRF2, DKFZp781H1715
DNA
TYPE functioning gene
STRUCTURE 265.40 kb     27 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
BHMT 5q13.1-q15 betaine-homocysteine methyltransferase JMY 5q14.1 junction-mediating and regulatory protein HOMER1 5q25 homer homolog 1 (Drosophila) LOC133748 5q14.1 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) FLJ38499 5q14.1 hypothetical protein FLJ38499 CMYA5 5q14.1 cardiomyopathy associated 5 LOC391802 5 similar to 60S ribosomal protein L10 (QM protein homolog) LOC345778 5q14.1 similar to hypothetical protein THBS4 5q13 thrombospondin 4 C5orf12 5 chromosome 5 open reading frame 12 LOC391803 5 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC134478 5q14.1 similar to cytoplasmic beta-actin NYD-TSP1 5q14.1 testis-specific protein NYD-TSP1 LOC391804 5 similar to hypothetical protein LOC391805 5 hypothetical gene supported by NM_004269 LOC153817 5q14.1 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) ZFYVE16 5p15.2-q14.3 zinc finger, FYVE domain containing 16 LOC167555 5q14.1 similar to AASA9217 LOC340120 5q14.1 similar to RIKEN cDNA 6430502M16 gene LOC389306 5 LOC389306 DBIL1 5pter-p15.32 diazepam binding inhibitor-like 1 DHFR 5q13.2 dihydrofolate reductase MSH3 5q11-q12 mutS homolog 3 (E. coli) RASGRF2 5q13 Ras protein-specific guanine nucleotide-releasing factor 2 CKMT2 5q13.3 creatine kinase, mitochondrial 2 (sarcomeric) DKFZp761J139 5q14.1 hypothetical protein DKFZp761J139 CACH-1 5q14.1 cytosolic acetyl-CoA hydrolase SSBP2 5q14.1 single-stranded DNA binding protein 2 DSS1P1 5q14 single-stranded DNA binding protein 2 APG10L 5q14.1 APG10 autophagy 10-like (S. cerevisiae) PPIP1 5q14.1 peptidylprolyl isomerase (cyclophilin) pseudogene 1 RPS23 5q13-q14 ribosomal protein S23 LOC92270 5q14.1 hypothetical protein LOC92270
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 4078 140.6 1237 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
 parathyroid   moderately
Nervousbrain   moderately
Visualeye   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two pleckstrin (PH) homology domains
  • an ilimaquinone (IQ) domain mediating the calcium-dependent interaction with calmodulin but being dispensable for the Ras-GEF activity
  • the DH (DBL-homology) domain mediating interaction with RASGRF1 and EPB49 and being required for RAC1 activation
  • a Ras-GEF domain and an N-terminal Ras-GEF domain forming a Ras-binding site and mediate Ras activation
  • mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies homolog to rattus Rasgrf2 (95.9 pc)
    homolog to murine Rasgrf2 (95.5 pc)
    homolog to zebrafish rasgfr2 (86.1 pc)
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • functioning as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP
  • preferentially activating HRAS in vivo compared to RRAS based on their different types of prenylation
  • functioning in synaptic plasticity by contributing to the induction of long term potentiation
  • involved in T-cell receptor- and NF-AT-mediated immune responses
  • RASGRF1 and -GRF2 may act as adaptors that bind PLCG1 and restrict Ca2+ signalling to the vicinity of focal adhesions, indicating a new role for these GRFs that is required for IL1 induction of the RAS&
  • 8594;ERK pathway and MMP3 expression
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
  • regulation of Rho protein signal transduction
  • regulation of small GTPase mediated signal transduction
  • a component
  • heterooligomer with RASGRF1
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • interacting with Ras and RAC1
  • interacting in a calcium-dependent manner with calmodulin
  • interacting with CDK5R1 and EPB49
  • interacting with the AMPA receptor through GRIA1
  • interacting with microtubules
  • RASGRF1/2 associates with PLCG1
  • cell & other
    REGULATION
    Other phosphorylated by CDK5
    ubiquitinated upon interaction with Ras
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral imprinting      
    frequent methylation and silencing in the carcinogenesis of non-small cell lung cancer (NSCLC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS