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FLASH GENE
Symbol RASGEF1A contributors: mct - updated : 30-08-2011
HGNC name RasGEF domain family, member 1A
HGNC id 24246
Location 10q11.21      Physical location : 43.689.983 - 43.762.367
Synonym symbol(s) CG4853,FLJ37817
DNA
TYPE functioning gene
SPECIAL FEATURE
text 65kb 3' of RET
STRUCTURE 72.38 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3235 - 481 - 2009 19645719
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RasGEF-N domain
  • C-terminal CDC25-Ras exchange motif domain
  • HOMOLOGY
    Homologene
    FAMILY RasGEF1 family of proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • having guanyl-nucleotide exchange factor activity
  • RASGEF1A and RASGEF1B function as very specific exchange factors for RAP2A, a member of the Rap subfamily of Ras-like G-proteins
  • guanine nucleotide exchange factor that discriminate between Rap GTP-binding proteins and mediate RAP2A-specific nucleotide exchange
  • CELLULAR PROCESS nucleotide, repair, nucleotide excision repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • four candidate target genes for NO66, SBNO1, TGFBRAP1, RIOK1, and RASGEF1A, which were the most significantly induced by exogenous NO66 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS