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FLASH GENE
Symbol RASD1 contributors: mct/npt - updated : 24-04-2009
HGNC name RAS, dexamethasone-induced 1
HGNC id 15828
Location 17p11.2      Physical location : 17.397.754 - 17.399.707
Synonym name
  • Ras-related protein
  • activator G protein signaling 1
  • dexamethasone-induced ras-related protein 1
    • Synonym symbol(s) AGS1, DEXRAS1, MGC:26290
    DNA
    TYPE functioning gene
    STRUCTURE 1.96 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   HRE
    text structure a glucocorticoid response element (GRE) was identified in the 3'-flanking region (2.3 kb downstream of poly(A) signal)
    MAPPING cloned Y linked N status confirmed
    Map see SMCR (phenotype)
    regionally located the Smith-Magenis critical region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1758 31.5 281 - Fang (2000)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineneuroendocrinepituitary  highly
     pancreas   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • P loop
  • guanine base-binding loops
  • C terminal farnesylation site, an extended C terminus that is found to interact with the PTB domain of NOS1AP (Lau 2008)
    • HOMOLOGY
    interspecies homolog to murine Rasd1
    Homologene
    FAMILY
  • small GTPase superfamily
  • RasD family
    • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text found in the nucleus (Lau 2008)
    basic FUNCTION
  • playing a role in cell adhesion, extra-cellular matrix interactions, and in dexamethasone-induced alterations in cell morphology
  • acting to modulate the activation of adenylyl cyclase (ADCY2) in an indirect fashion by inhibiting both Gbetagamma- and PKC-stimulated ADCY2 activity and involved in signal transduction (Nguyen 2006)
  • physiologic Nitris oxide (No) effector and anchoring of neuronal Nitric oxide synthase to specific targets is a mechanism by which NO signaling is enhanced (Fang 2000)
  • functions as a suppressor of APBB1-APP-mediated transcription (Lau 2008)
  • brain-enriched member of the Ras family of small monomeric G proteins (Fang 2000)
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • with NOS1AP form a ternary complex that enhances the ability of neuronal nitric oxide synthase to activate RASD1 (Fang 2000)
  • with RASD1, RASD2 define a new group of Ras-like monomeric G proteins (Thapliyal 2008)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to APBB1 PTB2 domain and potently suppresses the APBB1-APP-mediated transcription (Lau 2008)
  • interacting with NOS1AP (Lau 2008)
  • RASD1 with RASD2 modulate Ca(2+) influx through Ca(V)2.2 channels under more physiological conditions and thereby influence Ca(2+)-dependent events such as neurosecretion (Thapliyal 2008)
    • cell & other
    REGULATION
    activated by dexamethasone
    by NO (nitric oxide) donors as well as by NMDA receptor-stimulated NO synthesis in cortical neurons (Fang 2000)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS