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FLASH GENE
Symbol RASD1 contributors: mct/npt - updated : 24-04-2009
HGNC name RAS, dexamethasone-induced 1
HGNC id 15828
Location 17p11.2      Physical location : 17.397.754 - 17.399.707
Synonym name
  • Ras-related protein
  • activator G protein signaling 1
  • dexamethasone-induced ras-related protein 1
  • Synonym symbol(s) AGS1, DEXRAS1, MGC:26290
    DNA
    TYPE functioning gene
    STRUCTURE 1.96 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   HRE
    text structure a glucocorticoid response element (GRE) was identified in the 3'-flanking region (2.3 kb downstream of poly(A) signal)
    MAPPING cloned Y linked N status confirmed
    Map see SMCR (phenotype)
    Physical map
    LOC147226 17p11.2 similar to yeast Upf3, variant A pseudogene LOC252841 17p11.2 signal recognition particle 68kD pseudogene LOC266619 17p11.2 nitric oxide synthase 2A (inducible, hepatocytes) pseudogene LOC353194 17p11.2 keratin pseudogene LOC388342 17 similar to Keratin, type I cytoskeletal 16 (Cytokeratin 16) (K16) (CK 16) LOC388343 17 similar to Keratin, type I cytoskeletal 14 (Cytokeratin 14) (K14) (CK 14) LOC147228 17p11.2 keratin pseudogene LOC339186 17p11.2 keratin pseudogene CLPSMCR 17p11.2 coactosin-like, Smith Magenis syndrome chromosome region LOC390768 17 similar to FLJ00050 protein LOC96597 17p11.2 hypothetical protein LOC96597 TNFRSF13B 17p11.2 tumor necrosis factor receptor superfamily, member 13B M-RIP 17p11.2 myosin phosphatase-Rho interacting protein LOC201164 17p11.2 similar to CG12314 gene product BHD MGC13008 17p11.2 hypothetical protein MGC13008 LOC390769 17 similar to actin 3 - fruit fly (Drosophila melanogaster) (fragments) COPS3 17p11.2 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) NT5M 17p11.2 5',3'-nucleotidase, mitochondrial LOC388344 17 similar to ribosomal protein L13; 60S ribosomal protein L13; breast basic conserved protein 1 FLJ10193 RASD1 17p11.2 RAS, dexamethasone-induced 1 PEMT 17p11.2 phosphatidylethanolamine N-methyltransferase FLJ23022 17p11.2 hypothetical protein FLJ23022 RAI1 17p11.2 retinoic acid induced 1 SMCR5 17p11.2 Smith-Magenis syndrome chromosome region, candidate 5 SREBF1 17p11.2 sterol regulatory element binding transcription factor 1 TOM1L2 17p11.2 target of myb1-like 2 (chicken) DKFZP586M1120 17p11.2 hypothetical protein DKFZp586M1120 ATPAF2 17p11.2 ATP synthase mitochondrial F1 complex assembly factor 2 MGC3048 17p11.2 hypothetical protein MGC3048 DRG2 17p11.2 developmentally regulated GTP binding protein 2
    regionally located the Smith-Magenis critical region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1758 31.5 281 - Fang (2000)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineneuroendocrinepituitary  highly
     pancreas   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • P loop
  • guanine base-binding loops
  • C terminal farnesylation site, an extended C terminus that is found to interact with the PTB domain of NOS1AP (Lau 2008)
  • HOMOLOGY
    interspecies homolog to murine Rasd1
    Homologene
    FAMILY
  • small GTPase superfamily
  • RasD family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text found in the nucleus (Lau 2008)
    basic FUNCTION
  • playing a role in cell adhesion, extra-cellular matrix interactions, and in dexamethasone-induced alterations in cell morphology
  • acting to modulate the activation of adenylyl cyclase (ADCY2) in an indirect fashion by inhibiting both Gbetagamma- and PKC-stimulated ADCY2 activity and involved in signal transduction (Nguyen 2006)
  • physiologic Nitris oxide (No) effector and anchoring of neuronal Nitric oxide synthase to specific targets is a mechanism by which NO signaling is enhanced (Fang 2000)
  • functions as a suppressor of APBB1-APP-mediated transcription (Lau 2008)
  • brain-enriched member of the Ras family of small monomeric G proteins (Fang 2000)
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • with NOS1AP form a ternary complex that enhances the ability of neuronal nitric oxide synthase to activate RASD1 (Fang 2000)
  • with RASD1, RASD2 define a new group of Ras-like monomeric G proteins (Thapliyal 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to APBB1 PTB2 domain and potently suppresses the APBB1-APP-mediated transcription (Lau 2008)
  • interacting with NOS1AP (Lau 2008)
  • RASD1 with RASD2 modulate Ca(2+) influx through Ca(V)2.2 channels under more physiological conditions and thereby influence Ca(2+)-dependent events such as neurosecretion (Thapliyal 2008)
  • cell & other
    REGULATION
    activated by dexamethasone
    by NO (nitric oxide) donors as well as by NMDA receptor-stimulated NO synthesis in cortical neurons (Fang 2000)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS