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FLASH GENE
Symbol RASAL1 contributors: - updated : 08-09-2005
HGNC name RAS protein activator like 1 (GAP1 like)
HGNC id 9873
Location 12q23-q24      Physical location : 113.536.624 - 113.574.044
DNA
TYPE functioning gene
STRUCTURE 36.00 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
BRAP 12q24 BRCA1 associated protein MGC5601 12q24.13 hypothetical protein MGC5601 ALDH2 12q24.2 aldehyde dehydrogenase 2 family (mitochondrial) FLJ39616 12q24.13 apoptosis-related protein PNAS-1 MAPKAPK5 12q24.12 mitogen-activated protein kinase-activated protein kinase 5 ADAM1 12q24.13 a disintegrin and metalloproteinase domain 1 (fertilin alpha) pseudogene LOC89894 12q24.13 hypothetical protein BC000282 C12orf8 12q24.13 chromosome 12 open reading frame 8 FLJ13089 12q24.13 hypothetical protein FLJ13089 FLN29 12q FLN29 gene product FLJ30092 12q24.13 AF-1 specific protein phosphatase FLJ34154 12q24.13 hypothetical protein FLJ34154 RPL6 12q23-q24.1 ribosomal protein L6 PTPN11 12q24.1 protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) RPH3A 12q24.11 protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) OAS1 12q24.2 2',5'-oligoadenylate synthetase 1, 40/46kDa OAS3 12q24.1 2'-5'-oligoadenylate synthetase 3, 100kDa OAS2 12q24.2 2'-5'-oligoadenylate synthetase 2, 69/71kDa DTX1 12q24.1 deltex homolog 1 (Drosophila) RASAL1 12q23-q24 RAS protein activator like 1 (GAP1 like) LOC387885 12 LOC387885 DDX54 12q24.21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 FLJ14827 12q24.21 hypothetical protein FLJ14827 LOC115811 12q24.21 hypothetical protein BC013151 TPCN1 12q24.21 two pore segment channel 1 FLJ22233 LOC196463 12q24.21 hypothetical protein LOC196463 SDS 12q24.1 serine dehydratase SDS-RS1 12q24.21 serine dehydratase related sequence 1 LHX5 12q24.31-q24.32 LIM homeobox protein 5 KIAA0682 12q23.3-q24.2 LIM homeobox protein 5 TBX5 12q24.1 T-box 5 LOC387886 12 LOC387886 LOC390361 12 similar to microtubule-associated proteins 1A/1B light chain 3
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
Endocrineadrenal glandmedulla   
 thyroid    
Lymphoid/Immunelymph node   predominantly
Nervousbrain   moderately
Reproductivefemale systemuterus  highly
Respiratorylung   highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Nervousautonomous   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticfollicular dendritic
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-terminal calcium-dependent phospholipid C2 binding domains
  • one conserved GAP related domain
  • BTK motif
  • one C-terminal PH domain
  • HOMOLOGY
    interspecies homolog to murine Rasal domain
    Homologene
    FAMILY GAP1 family of GTPase-activating protein
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as a suppressor of RAS function
  • controling cellular proliferation and differentiation
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • intracellular signaling cascade
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by PITX1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS