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FLASH GENE
Symbol RASAL1 contributors: - updated : 08-09-2005
HGNC name RAS protein activator like 1 (GAP1 like)
HGNC id 9873
Location 12q23-q24      Physical location : 113.536.624 - 113.574.044
DNA
TYPE functioning gene
STRUCTURE 36.00 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
Endocrineadrenal glandmedulla   
 thyroid    
Lymphoid/Immunelymph node   predominantly
Nervousbrain   moderately
Reproductivefemale systemuterus  highly
Respiratorylung   highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Nervousautonomous   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticfollicular dendritic
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-terminal calcium-dependent phospholipid C2 binding domains
  • one conserved GAP related domain
  • BTK motif
  • one C-terminal PH domain
  • HOMOLOGY
    interspecies homolog to murine Rasal domain
    Homologene
    FAMILY GAP1 family of GTPase-activating protein
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as a suppressor of RAS function
  • controling cellular proliferation and differentiation
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • intracellular signaling cascade
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by PITX1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS