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FLASH GENE
Symbol RASA3 contributors: mct - updated : 27-02-2015
HGNC name RAS p21 protein activator 3
HGNC id 20331
Location 13q34      Physical location : 114.747.194 - 114.898.095
Synonym name
  • GTPase activating protein III
  • Ins(1,3,4,5)P4-binding protein
  • inositol 1,3,4,5-tetrakisphosphate-binding protein
  • Synonym symbol(s) GAP1IP4BP, GAPIII, MGC46517, MGC47588
    DNA
    TYPE functioning gene
    STRUCTURE 154.84 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC387949 13 LOC387949 ATP11A 13q34 ATPase, Class VI, type 11A LOC387950 13 LOC387950 MCF2L 13q34 MCF.2 cell line derived transforming sequence-like F7 13q34 coagulation factor VII (serum prothrombin conversion accelerator) F10 13q34 coagulation factor X PROZ 13q34 protein Z, vitamin K-dependent plasma glycoprotein FLJ11305 13q34 hypothetical protein FLJ11305 CUL4A 13q34-qter cullin 4A LAMP1 13q34 lysosomal-associated membrane protein 1 GRTP1 4q14 growth hormone regulated TBC protein 1 LOC387951 13 LOC387951 ADPRHL1 13q34 ADP-ribosylhydrolase like 1 C13orf17 13q34 chromosome 13 open reading frame 17 C13orf11 13q34 chromosome 13 open reading frame 11 TFDP1 13q34 transcription factor Dp-1 ATP4B 13q34 ATPase, H+/K+ exchanging, beta polypeptide RHOK 13q34 rhodopsin kinase LOC387952 13 hypothetical gene supported by AK126042; BC034570 GAS6 13q34 growth arrest-specific 6 MGC20579 13q34 hypothetical protein MGC20579 RASA3 13q34 RAS p21 protein activator 3 LOC390427 13 LOC390427 CDC16 13q34 CDC16 cell division cycle 16 homolog (S. cerevisiae) UPF3A 13q34 UPF3 regulator of nonsense transcripts homolog A (yeast) C13orf8 13q34 chromosome 13 open reading frame 8
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 4220 - 834 - 2000 10828023
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Mus musculusFetal
    Lymphoid/Immunespleen     Mus musculusAdult
     spleen     Mus musculusFetal
     thymus     Mus musculusFetal
    Respiratorylung     Mus musculusFetal
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly Mus musculusFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Mus musculusFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • BTK motif
  • PH domain
  • C2A and C2B domains are involved in membrane binding and calcium-dependent activation of some GAPs, and catalytic activity of RASA3 is located within the RasGAP domain
  • protein kinase C conserved region
  • HOMOLOGY
    interspecies homolog to murine Rasa3
    Homologene
    FAMILY GAP1 family of GTPase activating protein
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • constitutively bound to the membrane via interactions of its pleckstrin homology (PH) domain with PIP2 and PIP3
  • basic FUNCTION
  • stimulates the GTPase activity of normal RAS p21
  • suppressor of RAS function
  • role in intracellular calcium homeostasis
  • might be a specific IP4 receptor
  • critical, conserved, and nonredundant role for RASA3 in vertebrate hematopoiesis
  • RASA3 catalytic activity controls likely RBGEF1 activation and integrin signaling during megakaryocyte differentiation
  • function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    binds inositol tetrakisphosphate with high affinity
    protein
  • links GNAI1 proteins to inhibit GNAQ-induced RAS/ERK1/2 activation
  • RASA3 targets RAS and RABGEF1
  • P2RY12 signaling is required to inhibit RASA3 and enable sustained RABGEF1-dependent platelet activation and thrombus formation at sites of vascular injury
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in mice, reduced expression of Rasa3 led to premature platelet activation and markedly reduced the life span of circulating platelets
  • Rasa3 catalytic inactivation in mouse hematopoietic cells results in a lethal syndrome characterized by severe defects during megakaryopoiesis, thrombocytopenia and a predisposition to develop preleukemia
  • scat phenotype is due to a mutation in Rasa3 with its mislocalization leading to its loss of function, and to crisis and remission episodes