Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RASA2 contributors: - updated : 07-09-2006
HGNC name RAS p21 protein activator 2
HGNC id 9872
Location 3q22-q23      Physical location : 141.205.925 - 141.331.197
Synonym name GTPase-activating protein of RAS
Synonym symbol(s) GAP1M
DNA
TYPE functioning gene
STRUCTURE 125.00 kb     24 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC391582 3 similar to ATP synthase lipid-binding protein, mitochondrial precursor (ATP synthase proteolipid P1) (ATPase protein 9) (ATPase subunit C) LOC389150 3 LOC389150 FOXL2 3q23 forkhead box L2 LOC389151 3 hypothetical gene supported by AK127998 LOC389152 3 hypothetical gene supported by AK128089 BPESC1 3q23 blepharophimosis, epicanthus inversus and ptosis, candidate 1 MRPS22 3q23 mitochondrial ribosomal protein S22 COPB2 3q23 coatomer protein complex, subunit beta 2 (beta prime) RBP2 3q23 retinol binding protein 2, cellular ACTGP1 3q22.3 actin, gamma pseudogene 1 RBP1 3q23 retinol binding protein 1, cellular NMNAT3 3q12.1-3q13.11 nicotinamide nucleotide adenylyltransferase 3 FLJ11827 3q22.3 hypothetical protein FLJ11827 CLSTN2 3q23-q24 calsyntenin 2 TRIM42 3q23-24 tripartite motif-containing 42 LOC391583 3 similar to 60S ribosomal protein L23a FLJ10618 3q23 hypothetical protein FLJ10618 SSB4 3q23 SPRY domain-containing SOCS box protein SSB-4 FLJ23751 3q23 hypothetical protein FLJ23751 FLJ35036 3q23 hypothetical protein FLJ35036 LOC391584 3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) RASA2 3q22-q23 RAS p21 protein activator 2 LOC389153 3 LOC389153 LOC391585 3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) RNF7 3q22-q24 ring finger protein 7 GPRK7 3q21-q24 G protein-coupled receptor kinase 7 ATP1B3 3q22-q23 ATPase, Na+/K+ transporting, beta 3 polypeptide TFDP2 3q23 transcription factor Dp-2 (E2F dimerization partner 2) MGC40579 3q23 hypothetical protein MGC40579 SEP1 3q23 strand-exchange protein 1 ATR 3q22-q24 ataxia telangiectasia and Rad3 related PLS1 3q23 plastin 1 (I isoform) TRPC1 3q22-q24 transient receptor potential cation channel, subfamily C, member 1 PCOLCE2 3q21-q24 procollagen C-endopeptidase enhancer 2 PAQR9 3q23 progestin and adipoQ receptor family member IX SR140 3q23-q24 progestin and adipoQ receptor family member IX LOC389154 3 LOC389154 CHST2 3q24 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 PBXP1 3q22-q23 pre-B-cell leukemia transcription factor pseudogene 1 SLC9A9 3p14 solute carrier family 9 (sodium/hydrogen exchanger), isoform 9 LOC257039 3q24 similar to ribosomal protein S17 MGC33365 3q24 hypothetical protein MGC33365
RNA
TRANSCRIPTS type messenger
text with a placenta specific isoform
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 pharynx   highly
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin (PH) homology domain
  • a GTPase activating protein (signal transduction)
  • RAS-GAP domain
  • two C2 domains
  • a BTK-type zinc finger domain
  • HOMOLOGY
    Homologene
    FAMILY GAP1 family of GTPase-activating proteins
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text perinuclear region
    basic FUNCTION
  • inhibitory regulator of the RAS-cyclic Amp pathway, enhancing the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds inositol tetrakisphosphate
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS