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FLASH GENE
Symbol RARRES1 contributors: mct - updated : 24-08-2022
HGNC name retinoic acid receptor responder (tazarotene induced) 1
HGNC id 9867
Location 3q25.32      Physical location : 158.414.898 - 158.450.275
Synonym name
  • tazarotene-induced gene 1
  • RAR-responsive protein
  • latexin-like
  • phorbol ester-induced gene 1 protein
    • Synonym symbol(s) HGNC9867, TIG1, LXNL, PERG-1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 35.57 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1713 - 294 - 2011 21303978
    4 - 854 - 228 frequently downregulated in various cancer tissues 2011 21575264
  • TIG1B
  • inhibits growth and invasion of cancer cells
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly Homo sapiens
    Reproductivefemale systembreastmammary gland highly
     male systemtestis  highly Homo sapiens
     male systemprostate  highly Homo sapiens
    Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
    Visualeye   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Rarres1
    Homologene
    FAMILY
  • steroid and thyroid hormone receptor superfamily of transcriptional regulators
  • protease inhibitor I47 (latexin) family
    • CATEGORY tumor suppressor , receptor nuclear
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    text
  • type II membrane protein
  • RARRES1 is not a plasma membrane protein as previously supposed but is located primarily in the endoplasmic reticulum
    • basic FUNCTION
  • playing a role in colorectal epithelial differentiation
  • plays an important role in regulating proliferation and differentiation of adipose tissue-derived mesenchymal stem cells
  • function as a cell adhesion molecule, which leads to better cell to cell contact and reduced proliferation
  • RARRES1, AGBL2, KIF11, another EEY-bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis
  • retinoid-inducible type II tumour suppressor gene (
  • may participate in the downregulation of G-protein coupled signaling by upregulating GRK5 expression
  • tumor suppressive roles exerted by RARRES1 in part by promoting breast epithelial cell death and by impeding cell invasion, is an important property for metastatic spread
  • retinoid-regulated tumor suppressor
  • important role of RARRES1 in podocyte injury in glomerular disease
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • transmembrane carboxypeptidase inhibitor that interacts with ATP/GTP binding protein-like 2 (AGBL2)
  • interacting with GRK5
  • RARRES1 interacts with SPINK2 in NT2/D1 testicular carcinoma cells, and interaction between TIG1 and SPINK2 plays an important role in the inhibition of testicular cancer cell EMT
    • cell & other
    REGULATION
    Other upregulated by the synthetic, retinoid tazarotene
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    in nasopharyngeal carcinoma, by promoter hypermethylation
    tumoral     --low  
    through DNA hypermethylation in several types of malignant tissues
    constitutional     --over  
    in terminally differentiated cells of normal mucosal tissues and all adenoma tissues
    tumoral     --low  
    in colon cancer cell lines
    tumoral       loss of function
    undergoes frequent epigenetic inactivation due to aberrant DNA hypermethylation in gastric cancers, and its altered expression is associated with the malignant progression of tumors
    tumoral     --low  
    in testicular cancer tissues
    constitutional     --over  
    in the endothelial cells in some diseased kidneys to promote podocyte injury, likely through a paracrine effect
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential target for cancers
    metabolismlipidcholesterol
    potential target for diseases with impaired fatty acid metabolism
    ANIMAL & CELL MODELS