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FLASH GENE
Symbol RARG contributors: mct - updated : 07-12-2016
HGNC name retinoic acid receptor, gamma
HGNC id 9866
Location 12q13.13      Physical location : 53.604.353 - 53.626.036
Synonym symbol(s) HGNC9866, RARC, NR1B3, RRG1, EVI22
DNA
TYPE functioning gene
STRUCTURE 21.68 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2992 - 454 - -
8 - 2740 - 443 - -
- - 2666 - 382 - -
- - 2517 - 333 - -
- - 2631 - 432 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one modulating N terminal domain
  • a zinc finger DNA binding
  • a C terminal steroid binding domain
  • AF-1 and AF-2 domains involved in the processes of transactivation and degradation
  • HOMOLOGY
    interspecies homolog to murine Rarg
    Homologene
    FAMILY steroid/thyroid hormone receptor superfamily
    CATEGORY transcription factor , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • cytoplasmic retention of RARG was due to the presence of its unique N-terminal A/B domain, which was subject to regulation by MAPK14 -mediated phosphorylation
  • basic FUNCTION
  • ligand activated transcription factor
  • mediator of retinoids induced apoptosis in pancreatic cancer cells
  • regulates CNR1 expression and is thus involved in the control of hepatic fat metabolism by endocannabinoid
  • in the absence of its ligand RA (retinoic acid), is required for deposition of the histone variant H2AFZ and the polycomb group protein SUZ12 at RA target genes, and in embryonic stem cells both RARG and SUZ12 exist in a multi-protein complex in the absence of ligand
  • RARG and NR5A2 promote conversion of fibroblasts to functional neurons
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • RARG/RXRA heterodimers
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • its subcellular localization is regulated by complex interactions among ligand binding, receptor phosphorylation, and receptor dimerizations
  • SORBS3 is a new partner of the RARG N-Terminal domain
  • FBXO30 acts as an E3 ubiquitin ligase and targets RARG for ubiquitination and proteasomal degradation
  • cell & other
    REGULATION
    activated by both all-trans (T-RA) and its 9-cis isomer (9-cis-RA) retinoic acids
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    loss of RARG results in a nonhematopoietic cell-intrinsic myeloproliferative syndromes, revealing the capability of the microenvironment to be the sole cause of hematopoietic disorders
    Susceptibility to meningomyelocele (MM)
    Variant & Polymorphism SNP
  • rs3741434 conferred a protective effect for MM susceptibility (MID: 21254357)
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularboneaquired
    RARG agonists are potent inhibitors of heterotopic ossification, and may also be effective against injury-induced and congenital heterotopic ossification
    ANIMAL & CELL MODELS
  • Rargamma(-/-) mice had significantly increased granulocyte/macrophage progenitors and granulocytes in bone marrow (BM), peripheral blood, and spleen