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FLASH GENE
Symbol RAPGEF5 contributors: np - updated : 26-03-2003
HGNC name Rap guanine nucleotide exchange factor (GEF) 5
HGNC id 16862
Location 7p21.3      Physical location : 22.157.908 - 22.396.533
Synonym name
  • guanine nucleotide exchange factor for Rap1
  • M-Ras-regulated GEF
  • related to Epac
  • M-Ras-regulated Rap GEF
  • Synonym symbol(s) MR-GEF, KIAA0277, GFR, REPAC
    DNA
    TYPE functioning gene
    STRUCTURE 196.00 kb     26 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 6629 - 730 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Ras-GEF domain
  • PDZ domain containing guanine nucleotide exchange factor (GEF)1
  • HOMOLOGY
    Homologene
    FAMILY
  • guanine nucleotide exchange factor for Ras-like GTPases family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION activating Rap1
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding specifically to nucleotide-free Rap1
  • binding M-Ras-GTP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS