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FLASH GENE
Symbol RAP2C contributors: mct - updated : 16-12-2014
HGNC name RAP2C, member of RAS oncogene family
HGNC id 21165
Location Xq26.2      Physical location : 131.337.053 - 131.352.189
Synonym symbol(s) DKFZp313B211
DNA
TYPE functioning gene
STRUCTURE 16.46 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CXorf9 Xq26 chromosome X open reading frame 9 ZDHHC9 9 zinc finger, DHHC domain containing 9 LOC347465 Xq26.1 similar to sal-like 4 SDCCAG16 Xq26.1 serologically defined colon cancer antigen 16 FLJ11362 Xq25-q26.1 hypothetical protein FLJ11362 ELF4 Xq26 E74-like factor 4 (ets domain transcription factor) PDCD8 Xq25-q26 programmed cell death 8 (apoptosis-inducing factor) RAB33A Xq26.1 RAB33A, member RAS oncogene family FLJ20095 Xq26.1 hypothetical protein FLJ20095 SLC25A14 Xq24 solute carrier family 25 (mitochondrial carrier, brain), member 14 GPR119 Xq26.1 G protein-coupled receptor 119 CGI-79 Xq26.3-q27.3 G protein-coupled receptor 119 HT011 Xq26.1 uncharacterized hypothalamus protein HT011 COVA1 Xq25-q26.2 cytosolic ovarian carcinoma antigen 1 FLJ30058 Xq26.1 hypothetical protein FLJ30058 IGSF1 Xq25 immunoglobulin superfamily, member 1 LOC392540 X similar to olfactory receptor GA_x6K02T2Q64A-11927171-11926215 LOC392541 X similar to olfactory receptor MOR216-1 OR1AA1P Xq26.2 olfactory receptor, family 1, subfamily AA, member 1 pseudogene LOC392542 X similar to NACHT, leucine rich repeat and PYD containing 7; PYRIN-containing Apaf1-like protein 3; NACHT, LRR and PYD containing protein 7 LOC347468 Xq26.2 similar to Olfactory receptor 13H1 OR7L1P Xq26.2 olfactory receptor, family 7, subfamily L, member 1 pseudogene OR2AF2P Xq26.2 olfactory receptor, family 2, subfamily AF, member 2 pseudogene LOC389886 X similar to hypothetical protein MGC15416 MST4 Xq26.1 similar to hypothetical protein MGC15416 LOC90167 Xq26.2 hypothetical protein LOC90167 LOC392543 X similar to hypothetical protein FLJ10842 RAP2C Xq25 RAP2C, member of RAS oncogene family MBNL3 Xq26.2 muscleblind-like 3 (Drosophila) HS6ST2 Xq26.1-q26.2 heparan sulfate 6-O-sulfotransferase 2 USP26 Xq26.2 ubiquitin specific protease 26 LOC51270 Xq26.2 E2F-like protein GPC4 Xq26.1 glypican 4 GPC3 Xq26.1 glypican 3 LOC347475 Xq26.3 hypothetical gene supported by BC017958 LOC392544 X hypothetical gene supported by NM_152729 PHF6 Xq26 PHD finger protein 6 HPRT1 Xq26.1 hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome) MGC16121 Xq26.3 hypothetical protein MGC16121
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 3933 - 183 - 2007 17447155
6 - 3341 - 117 - 2007 17447155
6 - 4006 - 183 - 2007 17447155
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinerectum highly
 liver   highly
 stomach   predominantly
Reproductivefemale systemuterus  highly
 male systemprostate  predominantly
Urinarybladder   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal predominantly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmegakaryocyte
Blood/Hematopoieticplatelet
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RAS domain
  • a CAAX motif at the C-terminus
  • conjugated LipoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Rap2c
    homolog to rattus LOC302495
    Homologene
    FAMILY
  • small GTPase superfamily
  • Ras family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • localizing and recruiting TNIK to the recycling endosomes in a palmitoylation dependent manner (Uechi, 2009)
  • basic FUNCTION
  • signal transduction activity
  • may be involved in serum response element-mediated gene transcription
  • contribute to the still poorly clarified cellular events regulated by this subfamily of GTP-binding proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • bind guanine nucleotides with peculiar properties
  • F11R associates directly with TJP2 and indirectly with afadin, and this complex, along with RAPGEF2, activates the small GTPase RAP2C
  • is spatially segregated from RAP2A signaling as it is not enriched at the apical membrane after polarization
  • cell & other
    REGULATION
    repressed by during platelets generation
    Other requires palmitoylation for induction of TNIK-mediated phenotype, the suppression of cell spreading (Uechi, 2009)
    requires palmitoylation for membrane association and TNIK activation (Uechi, 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS